Mouse Anti-VCAM-1 Monoclonal Antibody (CBP2738)

Product Overview

Description

Vascular cell adhesion molecule 1 (VCAM1) is a 110-kDa transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. VCAM1 is expressed by cytokine-activated endothelium, interacts with integrin VLA4 (α4β1) present on the surface of leukocytes, and mediates both adhesion and signal transduction. It is also expressed either constitutively or inducibly in a variety of other cell types, including vascular smooth muscle cells, differentiating skeletal muscle cells, renal and neural epithelial cells, macrophages (Kupffer cells), dendritic cells, and bone marrow stromal cells.

Expression Host

Mammalian cells

Immunogen

VCAM-1 fusion protein Ag24697

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2738

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1500 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

VCAM1

Official Name

VCAM1

Full Name

Vascular cell adhesion molecule 1

Alternative Names

CD106; INCAM 100; V CAM 1; VCAM 1; VCAM1; VCAM-1

Gene ID

7412(Human); 22329(Mouse); 25361(Rat)

Uniprot ID

P19320(Human); P29533(Mouse); P29534(Rat)

References

1. Ma, X., Zhang, J., Wu, Z., & Wang, X. (2020). Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses. Journal of Receptors and Signal Transduction, 1-15. 2. Pan, T. J., Li, L. X., Zhang, J. W., Yang, Z. S., Shi, D. M., Yang, Y. K., & Wu, W. Z. (2019). Antimetastatic effect of fucoidan-sargassum against liver cancer cell invadopodia formation via targeting integrin αvβ3 and mediating αVβ3/Src/E2F1 signaling. Journal of Cancer, 10(20), 4777. 3. Yu, J., Ming, H., Li, H. Y., Yu, B., Chu, M., Zhu, H., & Zhu, X. (2019). IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling. Toxicology and applied pharmacology, 381, 114732.

Publications