Mouse Anti-S100B Monoclonal Antibody (CBP2814)

Product Overview

Description

S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs and has been implicated in the regulation of cellular activities such as metabolism, motility and proliferation. In the nervous system, S100B is constitutively released by astrocytes into the extracellular space and at nanomolar concentrations, it can promote neurite outgrowth and protect neurons against oxidative stress. Within the central nervous system (CNS), S100B is thought to be a marker for astroglial activation, linking astrocyte dysfunction to schizophrenia. In addition to astrocytes, S100B is released from many cell types, such as, adipocytes, chondrocytes, cardiomyocytes and lymphocytes. Serum S100B represents a new bomarker for mood disorders.

Expression Host

Mammalian cells

Immunogen

S100 Beta fusion protein Ag7440

Species Reactivity

Human; Porcine; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2814

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

S100 Beta

Official Name

S100B

Full Name

S100 calcium binding protein B

Alternative Names

NEF; Protein S100 B; S 100 protein beta chain; S 100 protein subunit beta; S100; S100 calcium binding protein B; S100B

Gene ID

6285(Human); 20203(Mouse); 25742(Rat)

Uniprot ID

P04271(Human); P50114(Mouse); P04631(Rat)

References

1. Xiaoying, L., Li, T., Yu, S., Jiusheng, J., Jilin, Z., Jiayi, W.,... & Yuhua, C. (2019). Resistin-Inhibited Neural Stem Cell-Derived Astrocyte Differentiation Contributes to Permeability Destruction of the Blood-Brain Barrier. Neurochemical research, 44(4), 905-916. 2. Wang, J., Zhou, F., Wang, D., Li, J., Lu, D., Li, Q.,... & Xie, J. (2018). Interaction of DCF1 with ATP1B1 induces impairment in astrocyte structural plasticity via the P38 signaling pathway. Experimental neurology, 302, 214-229.

Publications