Mouse Anti-Human AKT2 Monoclonal Antibody (CBP3712)

Product Overview

Description

AKT (Protein Kinase B, PKB) is a serine/threonine kinase that plays a key role in regulating cell survival, insulin signaling, angiogenesis, and tumor formation. AKT-AKT1, 2 and 3 have three isoforms, also known as PKBα, β and γ). More and more evidences show that AKT1, 2 and 3 play a unique role in the occurrence and development of breast cancer. The frequency of amplification or overexpression of AKT2 in cancer is higher than that found in AKT1. AKT2 is also closely related to type II diabetes and plays a key role in the phosphatidylinositol 3-kinase/Akt/mammalian target of the rapamycin (PI3K/mTOR) signal axis. The dysregulation of AKT2 is related to the acquisition of stem cell-like properties, which are responsible for aggressiveness and tumor progression, metastatic spread, and chemoresistance.

Immunogen

Purified recombinant fragment (a.a. 2-149) of human AKT2 expressed in E. coli.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP3712

Applications

Application Notes

WB (0.5-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

AKT2

Official Name

AKT2

Full Name

v-akt murine thymoma viral oncogene homolog 2

Alternative Names

AKT2; v-akt murine thymoma viral oncogene homolog 2

Gene ID

208(Human); 11652(Mouse); 25233(Rat)

Uniprot ID

P31751(Human); Q60823(Mouse); P47197(Rat)

References

1. Pereira L, et al. 2015. Drug Discov. Today 9:1152-8.
2. Yu H, et al. 2015. Vascul. Pharmacol. 71:57-64.
3. Cohen MM Jr. 2013. Am J. Med Genet A. 12:2931-7.
4. Dillon RL, Muller WJ. 2010. Cancer Res. 11:4260-4.
5. Song G, et al. 2005. J. Cell Mol. Med. 1:59-71.

Publications