Human Anti-Mouse Apo E 109-116 Monoclonal Antibody (CBP3722)

Product Overview

Description

Apolipoprotein E (ApoE) belongs to a class of apolipoproteins, which combine with lipids to form lipoproteins. ApoE is produced by macrophages in the liver and peripheral tissues and can regulate cholesterol metabolism. In the central nervous system, ApoE is mainly produced by astrocytes and plays an important role in transporting cholesterol to neurons through ApoE receptors. ApoE has three main isoforms corresponding to the three alleles (ApoE2, ApoE3 and ApoE4), which differ by only one or two amino acids at positions 112 and 158. ApoE4 is known to be one of the largest genetic risk factors for advanced Alzheimer's disease. In addition, ApoE4 is also associated with several other diseases, such as atherosclerosis, cognitive impairment and multiple sclerosis.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Human

Isotype

IgG2b, κ

Clone Number

CBP3722

Applications

WB; ELISA; IHC-P

Application Notes

WB (0.2-1.0 µg/mL); ELISA (0.004-0.4 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Apo E

Official Name

APOE

Full Name

Apolipoprotein E

Alternative Names

APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4

Gene ID

348 (Human); 11816 (Mouse)

Uniprot ID

P02649 (Human); P08226 (Mouse)

References

1. Mahley RW. 2016. Arterioscler Thromb Vasc Biol. 36: 1305-1315.
2. Riedel BC, et al. 2016 J Steroid Biochem Mol Biol. 160:134-47.
3. Tai LM, et al. 2016 Acta Neuropathol. 131(5):709-23.
4. Kim J, et al. 2014. Mol. Cells. 37:767
5. Holtzman DM, et al. 2012. Cold Spring Harb. Perspect. Med. 2:a006312

Publications