Mouse Anti-Human DOPA Decarboxylase Monoclonal Antibody (CBP3724)

Product Overview

Description

DOPA decarboxylase (DDC) is the enzyme that catalyzes several decarboxylation reactions including the conversion of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-Hydroxytryptophan (5-HTP) to serotonin, and L-tryotophan to tryptamine. DDC is the rate-limiting enzyme in dopamine synthesis in patients treated with L-DOPA and in serotonin synthesis in people treated with 5-HTP, such as those affected by Parkinson' disease and Depression, respectively. Thus, DDC is an important therapeutic target for these disorders. DDC deficiency is associated with severe developmental delay, oculogyric crises, and autonomic dysfunction.

Immunogen

Recombinant Human DOPA Decarboxylase (DDC) Protein

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3724

Applications

WB; IHC-P

Application Notes

WB (1.0-5.0 µg/mL); IHC-P (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

DDC

Official Name

DDC

Full Name

DOPA Decarboxylase

Alternative Names

Dopa Decarboxylase; DOPA Decarboxylase; EC 4.1.1.28; AADC; Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase); Aromatic L-Amino Acid Decarboxylase; Aromatic-L-Amino-Acid Decarboxylase; EC 4.1.1;

Gene ID

1644(Human); 13195(Mouse); 24311(Rat)

Uniprot ID

P20711(Human); O88533(Mouse); P14173(Rat)

References

1. Himmelreich N, et al. 2019. Mol Genet Metab. 127(1):12
2. Guenter J, et al. 2016. Postepy Hig Med Dosw. 70(0):1424
3. Montioli R, et al. 2016. Curr Drug Metab. 17(5):513

Publications