Rat Anti-Human β Amyloid Monoclonal Antibody (CBP3729)

Product Overview

Description

Alzheimer's disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

Immunogen

Recombinant human Abeta S26C dimer.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP3729

Applications

IHC-P; WB

Application Notes

IHC (1.0-5.0 µg/mL); WB (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Amyloid Beta

Official Name

β Amyloid

Full Name

β Amyloid

Alternative Names

APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; amyloid beta precursor protein; preA4

Gene ID

351 (Human); 11820 (Mouse); 54226 (Rat)

Uniprot ID

P05067 (Human); P12023 (Mouse); P08592 (Rat)

References

1. Selkoe DJ. 1994. Annu. Rev. Cell Biol 10:373-403.
2. O'Brien RJ, Wong PC. 2011. Annu. Rev. Neurosci. 34:185-204.
3. Chen GF, et al. 2017. Acta. Pharmacol. Sin. 38:1205-1235.

Publications