Anti-Rab8 Monoclonal Antibody (CBP3736)

[CAT#: NAB201299LS]

Anti-Rab8 Monoclonal Antibody [Biotin]

Host Species:: Mouse

Species Reactivity:: Human; Rat

Applications:: ICC

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Product Overview

Description

Rab8 is a small GTP/GDP binding protein that belongs to the RAS superfamily. Rab8 is an important participant of macroautophagy, and is essential for several apical transport pathways. Recruitment of Rab8a and TBK1 by the autophagy receptor optineurin initiates the autophagy process at specific protein aggregate site, which leads to the clearance of aggregated protein.

Immunogen

Recombinant human Rab8A

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3736

Applications

ICC

Application Notes

ICC (0.2-5.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Rab8

Official Name

RAB8A

Full Name

RAB8A

Alternative Names

RAB8A; MEL; RAB8; member RAS oncogene family

Gene ID

4218 (Human); 17274 (Mouse)

Uniprot ID

P61006 (Human); P55258 (Mouse)

References

1. Zhang X and Gao N. 2016. Small GTPases. 7:59
2. Just WW and Peränen J. 2016. Biochim Biophys Acta. 1863:1006
3. Ao X, et al. 2014. Cell Death Differ. 21(3):348
4. Corbier C and Sellier C. 2017. Small GTPases. 8:181

Publications