Mouse Anti-Human Tau 15-25 Monoclonal Antibody (CBP3772)

[CAT#: NAB2012178LS]

Anti-Tau 15-25 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB

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Product Overview

Description

Tau proteins are microtubule-associated protein (MAPs) which are abundant in neurons of the central nervous system, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes and elsewhere. One of Tau's main functions is to modulate the stability of axonal microtubules. Tau is active primarily in the distal portions of axons providing microtubule stabilization as well as flexibility. Tau forms aggregates with specific structural properties referred to as Paired Helical Filaments (PHFs) that are a characteristic of many different types of dementias, known as tauopathies.

Immunogen

Preliminary assignment of its epitope indicates that it maps to amino acid residues 15-25 on the longest isoform of human Tau.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3772

Applications

Application Notes

WB (0.1- 0.5 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Tau 15-25

Official Name

Tau 15-25

Full Name

Tau 15-25

Alternative Names

Tau 15-25

Gene ID

4137(Human); 17762(Mouse); 29477(Rat)

Uniprot ID

P10636(Human); P10637(Mouse); P19332(Rat)

References

1. Augustinack JC, et al. 2002. Acta Neuropathol. 103(1):26-35. PubMed.
2. Seubert P, et al. 1995. J Biol Chem. 270(32):18917-22.PubMed.
3. Dong Y, et al. 2012. PLoS One 7(6):e39386. PubMed.

Publications