Mouse Anti-Human GDNF Monoclonal Antibody (CBP4017)

Product Overview

Description

Glial cell-derived neurotrophic factor (GDNF) is a member of the TGF-β superfamily and was first identified as a growth factor supporting the survival of embryonic midbrain neurons. GDNF has been shown to promote the development, differentiation, and survival of dopaminergic neurons by signaling through GDNF family receptor α-1 (GFRα1) and the coreceptor RET receptor tyrosine kinase.

Immunogen

Recombinant Human GDNF

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP4017

Applications

Block

Application Notes

Block (0.05-0.4 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.2 µm filtered in PBS, pH 7.2, containing no preservative.

Concentration

Batch Dependent

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GDNF

Official Name

GDNF

Full Name

Glial Cell Derived Neurotrophic Factor

Alternative Names

Astrocyte derived trophic factor; Astrocyte derived trophic factor 1; Astrocyte-derived trophic factor; ATF 1; ATF 2; Atf

Gene ID

2668(Human); 14573(Mouse); 25453(Rat)

Uniprot ID

P39905(Human); P48540(Mouse); Q07731(Rat)

References

1. Allen SJ, et al. 2013. Pharmacol Ther. 138:155.
2. Hendrich J, et al. 2012. Neuroscience. 219:204.
3. Hidalgo-Figueroa M, et al. 2012. J Neurosci. 32:864.
4. Pascual A, et al. 2011. J Mol Endocrinol. 3:R83-92.
5. Carnicella S, et al. 2009. Pharmacol Ther. 122:9.
6. Sariola H, et al. 2003. J Cell Sci. 116:3855.

Publications