Mouse Anti-Human APP Monoclonal Antibody (CBP4029)
[CAT#: NAB20121048LS]
Anti-APP Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Amyloid β (Aβ or amyloid β) represents a peptide of 36-43 amino acids in length. It is the main component of amyloid plaques in the brains of patients with Alzheimer's disease. Important. The peptide is produced by amyloid precursor protein (APP), which is cleaved by certain enzymes to produce Aβ. Aβ molecules can aggregate to form oligomers (called "seeds"), and it is thought that they can induce other Aβ molecules to also take the form of misfolded oligomers, resulting in a chain reaction similar to a virus infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The tau protein, another protein involved in Alzheimer's disease, also forms virus-like misfolded oligomers, and there is evidence that misfolded Aβ can induce misfolding of tau.
Immunogen
Monoclonal antibody against Amyloid Precursor Protein (APP).
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP4029
Applications
WB
Application Notes
WB (1.0- 10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
1.0 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Publications
Publications (0)
Kits
Neural Genes
Neural Cell Lines
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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