Mouse Anti-Human CXCL10 Monoclonal Antibody (CBP4030)

Product Overview

Description

CXCL10, also known as IP-10, is a 8.7 kD chemokine. It belongs to the CXC chemokine family. It is expressed by monocytes, fibroblasts, and endothelial cells in response to IFNγ. CXCL10 can interact with CXCR3 and plays an important role in immune cell trafficking, particularly of T cells, dendritic cells, and NK cells.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP4030

Applications

FC; WB

Application Notes

FCM (≤0.5 µg per million cells in 100 µL volume); WB (0.5-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CXCL10

Official Name

CXCL10

Full Name

chemokine (C-X-C motif) ligand 10

Alternative Names

gIP-10; INP10; 10 kDa interferon gamma-induced protein; IP-10; C-X-C motif chemokine 10; 1-73; Small-inducible cytokine B10; IFI10; Gamma-IP10; SCYB10; crg-2; C7; mob-1

Gene ID

3627(Human);15945(Mouse)

Uniprot ID

P02778(Human);P17515(Mouse)

References

1. Luster AD, et al. 1987. Proc. Natl. Acad. Sci. USA 84:2868.
2. Kaplan G, et al. 1987. J. Exp. Med. 166:1098.
3. Sarris AH, et al. 1993. J. Exp. Med. 178:1127.

Publications