Product
Rat Anti-Mouse Caspase 11 Monoclonal Antibody (CBP4240)
[CAT#: NAB210107LS]
Anti-Caspase 11 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Murine caspase-11 is an upstream protease of caspase-1 and interacts with the proform of caspase-1 which in turn activates IL-1 beta. Caspase-11 is not constitutively expressed in most cell types. Its expression can be upregulated by LPS, IFN-gamma, and other pro-inflammatory stimuli. NF-κB and STAT1 were reported to be involved in the activation. Caspase-11 knock -out mice were resistant to endotoxin shock and do not produce IL-1 after stimulation with LPS. Their production of IFN-gamma was also deficient.
Immunogen
His tagged bacterial fusion protein of p 30 of caspase 11
Species Reactivity
Mouse
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a
Clone Number
CBP4240
Applications
WB
Application Notes
WB (1-2 ug/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
Caspase 11
Official Name
CASP11
Full Name
Caspase 11
Alternative Names
Caspase 11; CASP11
References
1. Lee J et al. 2001. J. Biol. Chem. 276:32956
2. Schauvliege R et al. 2002. J. Biol. Chem. 277:41624
3. Wang S et al. 1998. Cell 92:501
2. Schauvliege R et al. 2002. J. Biol. Chem. 277:41624
3. Wang S et al. 1998. Cell 92:501
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
