Mouse Anti-Human AKR1B1 Monoclonal Antibody (CBP4350)

[CAT#: NAB2101132LS]

Anti-AKR1B1 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB; IHC-P

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Product Overview

Description

Aldo-keto reductase 1 member B1 (AKR1B1) is a member of AKR superfamily and catalyzes the NADPH-dependent reduction of a wide range of carbonyl-containing compounds to their corresponding metabolites. It also plays an important role in glucose metabolism. Elevated expression levels of AKR1B1 correlate with breast cancer, neuroinflammation, and astrocyte proliferation via modulating energy metabolism.

Immunogen

Purified recombinant human AKR1B1 protein.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4350

Applications

WB; IHC-P

Application Notes

WB ( 0.2 - 5.0 µg/mL); IHC-P (1.0 - 10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

AKR1B1

Official Name

AKR1B1

Full Name

Aldo-keto reductase family 1, member B1

Alternative Names

AKR1B1; ADR; ALDR1; ALR2; AR; aldo-keto reductase family 1; member B1 (aldose reductase); aldo-keto reductase family 1 member B

Gene ID

231

Uniprot ID

P15121

References

1. Chen X, et al. 2018. Neurochem Res. 43(8):1491-1499.
2. Steinhauser CB, et al. 2016. Biol Reprod. 95(5):108.
3. Wu X, et al. 2017. J Exp Med. 214(4):1065-1079.
4. Han J, et al. 2016. Proc Natl Acad Sci U S A. 113(50):14283-14288.

Publications