Rat Anti-Human Histone H4 Monomethyl (CBP4361)

[CAT#: NAB2101148LS]

Anti-Histone H4 Monomethyl(Lys20) Monoclonal Antibody

Host Species:: Rat

Species Reactivity:: Human

Applications:: ChIP; IHC-P; WB

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Product Overview

Description

Histone proteins are classified into core histones (H2A, H2B, H3, H4) and linker histones (H1, H5). Core histones form an octamer, which contains two H2A-H2B dimers and one H3-H4 tetramer. Core histones are predominantly globular except for the unstructured N-terminal tails. Posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, SUMOylation and ADP-ribosylation occur in histone tails.

Immunogen

This monoclonal antibody was raised against a synthetic peptide conjugated to KLH containing methylated lysine 20 of human Histone H4.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG

Clone Number

CBP4361

Applications

ChIP; IHC-P; WB

Application Notes

ChIP (1:50-1:100); IHC-P (1:100-1:200)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Histone-h4-trimethyl-lys-19

Official Name

H4F3

Full Name

Histone H4

Alternative Names

Histone H4; H4F3

Gene ID

4780

Uniprot ID

P62805

References

1. Chen HM, et al. 2015. Epigenetics and Dermatology. 409:441.
2. Wang Z, et al. 2008. Nat. Genet. 40:897.
3. Beck DB, et al. 2012. Genes Dev. 26:325.

Publications