Mouse Anti-GRB2 Monoclonal Antibody (CBP4365)

Product Overview

Description

Growth factor receptor bound protein 2 (GRB2) is an adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. GRB2 is ubiquitously expressed, and has been shown to be essential to various cellular functions. Due to its involvement in cell growth, cell proliferation and metabolism, GRB2 has been linked to multiple tumor malignancies, and thus is a potential therapeutic target for cancer therapy. Recent neurodevelopmental studies also suggest that variations in intracellular levels of adapter proteins such as GRB2 may represent an underlying mechanism that links exogenous signals to cell fate determination.

Immunogen

Recombinant human GRB2

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4365

Applications

WB; IHC-P

Application Notes

WB (0.5-2 µg/mL); IHC-P ( 2-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.