NoGeneST™ Anti-TRPM2 Aptamer, aTRPM2 aptamer

Name: NoGeneST™ Anti-TRPM2 Aptamer, aTRPM2 aptamer
SKU: NRYF-0625-HZ115
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ115]

Aptamer designed to specifically recognize TRPM2, a cation channel that acts as a key sensor for oxidative stress.

Target:: TRPM2

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Product Overview

Relevant Diseases

Stroke

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

TRPM2

Full Name

Transient Receptor Potential Cation Channel Subfamily M Member 2

Alternative Names

TRPC7; LTRPC2

Gene ID

7226

Uniprot ID

O94759

Target Overview

Transient Receptor Potential Melastatin 2 (TRPM2) is a non-selective cation channel that functions as a crucial cellular sensor for oxidative stress. It is activated by intracellular ADP-ribose, which is produced under conditions of oxidative stress and DNA damage, leading to an influx of calcium (Ca2+) and other cations into the cell. By translating oxidative stress signals into changes in intracellular calcium levels, TRPM2 is involved in a wide range of physiological and pathological processes, including immune responses, insulin secretion, and programmed cell death. Its role in mediating neuronal death following ischemia makes it a target of interest for neuroprotective research.

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