Olfactory Bulbectomy (OBX) Depression Model Development Service

Are you currently facing long preclinical drug development cycles, limited translational validity in existing models, or challenges in identifying effective antidepressant compounds? Our olfactory bulbectomy (OBX) depression model development service helps you accelerate drug discovery and obtain robust, clinically relevant data through advanced preclinical modeling and a multi-faceted analysis platform.

The OBX model is a widely recognized animal model of depression that involves the surgical removal of the olfactory bulbs in rodents. This procedure induces a state of chronic stress, leading to long-lasting behavioral and neurobiological changes that closely resemble the symptoms of Major Depressive Disorder (MDD) in humans. The model has been instrumental in validating the efficacy of classic antidepressant drugs and remains a cornerstone for the preclinical discovery of new neurotherapeutics.

Workflow Advantages Available Models Offerings Related Services FAQs

How Our OBX Depression Model Development Service Can Assist Your Project

At Creative Biolabs, our service provides a robust and reliable platform for evaluating the efficacy and mechanism of action of novel antidepressant therapeutics. We offer a comprehensive solution that delivers quantifiable data, accelerating your journey from preclinical development to clinical success. Our capabilities are grounded in a deep understanding of the model's neurobiological and behavioral correlates with human depression, ensuring the data you receive is relevant and compelling.

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Workflow

The typical workflow for our OBX depression model development service is designed for transparency and scientific rigor, ensuring a seamless experience and clear, actionable results.

Workflow of our Olfactory Bulbectomy (OBX) Depression Model Development Service. (Creative Biolabs Original)

Required Starting Materials	To initiate a project, we require a detailed profile of your drug candidate, including its mechanism of action, route of administration, and solubility. We also need any existing in vitro or in vivo data you have to inform the study design.
Final Deliverables	Upon completion of the project, you will receive a detailed final report, raw and analyzed data files, and high-quality figures and graphs suitable for presentations and publications.
Estimated Timeframe	The typical timeframe for this service ranges from 8 to 12 weeks, depending on the number of cohorts, dosing regimen, and the specific behavioral and molecular assays included in the study.

Why Choose Us?

Choosing CBL for your preclinical research provides you with a distinct advantage. Our commitment to scientific excellence, combined with our deep expertise in the nuances of the OBX model, ensures we deliver data of the highest quality and translational relevance.

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Customer Reviews

Using their OBX depression model development service in our research has significantly improved the predictive validity of our compound screening, helping us de-risk our pipeline and focus on the most promising candidates.
The data quality and expert analysis we received from CBL were exceptional. Their team's understanding of the model's subtleties, particularly with different rat strains, prevented us from pursuing a less viable compound.
The streamlined workflow and clear communication from CBL's team made our research project run seamlessly.

Olfactory Bulbectomy (OBX) Depression Model

The OBX model is a valuable tool for studying the neurobiology of depression and assessing the efficacy of new drug candidates. The behavioral and neurobiological alterations it induces provide a robust, clinically relevant system. The model's utility is rooted in its ability to replicate key aspects of MDD, including anhedonia, hyperactivity, and neuroendocrine and immune system dysfunction. At CBL, we have refined our approach to this model, taking into account critical factors like animal strain and sex, to deliver highly reproducible and translatable data.

Fig.1 Sucrose preference test in the home cage of OBX and sham mice.¹

What We Can Offer

At CBL, our customized service offerings and scientific rigor provide a powerful solution for your research needs.

Tailored Study Design: We provide a fully customized service, adapting our protocols, behavioral assays, and molecular analysis to meet the specific requirements of your drug candidate and research hypothesis.
Guaranteed Model Stability: We ensure the stability and reproducibility of the OBX model, guaranteeing reliable and consistent data for your preclinical studies.
Optimized Methodologies: Our team constantly refines and optimizes our culture conditions and behavioral assays to maximize the yield of robust, translatable data.
Expert Protocol Management: We run the entire process with a professional, detail-oriented approach, ensuring every step, from surgical modeling to data delivery, is executed with precision.
Rigorous Quality Control: We utilize high-standard quality control tools to quantify and evaluate the quality of all data and deliverables, ensuring scientific accuracy and integrity.
Dedicated Scientific Team: Our experienced team provides personalized consultation and expert support throughout the entire project, ensuring seamless collaboration and effective problem-solving.

Related Services

To further support your project, CBL also offers a range of complementary services that can be integrated with our OBX depression model development service.

Target Identification & Validation
Compound Screening & Profiling
Pharmacokinetic/Pharmacodynamic (PK/PD) Studies
Neuroinflammation Research Models

FAQs

Q How does the OBX model compare to other depression models like the Forced Swim Test?

A The OBX model is a chronic, lesion-based model that induces long-lasting, depressive-like states, which is highly valuable for studying the efficacy of slow-acting antidepressants. In contrast, the Forced Swim Test is a situational stress model that assesses acute antidepressant effects. Our service can combine these models to provide a more comprehensive view of your compound's efficacy.

Q What are the key benefits of using your OBX model service?

A Our service offers significant advantages, including a refined, reproducible model, a full suite of behavioral and molecular assays, and expert data interpretation. We tailor our protocols to your specific needs, ensuring the highest relevance and helping you avoid common pitfalls associated with model variability.

We are ready to provide detailed information, answer your questions, and discuss your specific project needs.

Contact Our Team for More Information and to Discuss Your Project.

Reference

Coppola, David. "The Olfactory Bulbectomy Model of Depression: Brief History, Current Status and Critique." Brain Sciences 15.8 (2025): 775. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/brainsci15080775

For Research Use Only. Not For Clinical Use.

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