Organ-On-Chip Modeling Services

The translation of preclinical research into viable therapeutics has long been constrained by a fundamental disconnect: traditional in vitro models are static, while human biology is dynamic. Two-dimensional (2D) cell cultures fail to replicate the complex tissue architecture and mechanical forces of living organs, and animal models often fall short in predicting human-specific responses due to critical differences in genetics and physiology. This gap has created a significant bottleneck, particularly in neuroscience, where intricate cell-cell communication and barrier functions are paramount.

Creative Biolabs is breaking through this barrier with our Advanced Organ-on-Chip Modeling Services. By integrating human induced pluripotent stem cell (hiPSC)-derived organoids and tissues within sophisticated microfluidic devices, we engineer microphysiological systems (MPS) that recapitulate the dynamic, multi-cellular, and multi-organ environments of the human body. Our platforms provide a powerful, human-relevant system to dissect disease mechanisms, evaluate drug efficacy and safety, and accelerate the journey from discovery to validation.

Our Comprehensive Organ-on-a-Chip Portfolio

We have developed a suite of validated, organ-specific chip models designed to address the most pressing questions in biomedical research. Explore our specialized services below to discover how these advanced platforms can transform your studies.

Brain-on-a-Chip Modeling Service

Reconstruct functional human neural networks in a dynamic microenvironment. Our Brain-on-a-Chip models are ideal for studying neurogenesis, synaptogenesis, network activity, and the cellular mechanisms of neurodegenerative and neurodevelopmental disorders.

BBB-on-Chip Modeling Service

Model the highly selective barrier that protects the central nervous system. Our Blood-Brain Barrier (BBB)-on-a-Chip platform, featuring co-cultures of endothelial cells, pericytes, and astrocytes, is the gold standard for assessing drug permeability, transport mechanisms, and BBB integrity in response to disease or toxic insults.

Gut-Brain-on-Chip Modeling Service

Investigate the critical bidirectional communication between the enteric and central nervous systems. This advanced multi-organ chip integrates a functional intestinal epithelium with neural components to model gut-brain axis signaling, neuro-inflammation, and the pathophysiology of disorders from IBS to Parkinson's disease.

The Core Technology Powering Your Research

Our diverse service offerings are built upon a foundation of cutting-edge bioengineering and stem cell biology, ensuring the physiological relevance, reproducibility, and translatability of every model.

1. Human iPSC-Derived Biology: We eliminate the translational uncertainties of animal models by building our systems exclusively from human iPSCs. We can utilize patient-specific cell lines to capture unique genetic backgrounds or employ precise CRISPR-Cas9 gene editing to engineer disease mutations or reporter lines in a controlled, isogenic context.
2. Dynamic Microfluidic Environment: Our chips are more than just culture chambers. They are engineered microfluidic systems that provide continuous perfusion, mimicking physiological flow and shear stress. This dynamic environment is critical for enhancing cellular maturation, maintaining long-term viability, and allowing for precise control and real-time sampling of the cellular milieu.
3. Multi-Organ and Barrier Functionality: A key strength of our platform is the ability to connect different organ systems on a single chip. By engineering distinct but interconnected compartments, we can model complex inter-organ crosstalk, such as the gut-brain axis, or reconstruct critical biological barriers like the BBB with unparalleled structural and functional fidelity.
4. Integrated Sensing and Deep Phenotyping: Our platforms are designed for data-rich analysis. We can integrate real-time sensors for metrics like Trans-Epithelial Electrical Resistance (TEER) to continuously monitor barrier integrity. This is complemented by a full suite of advanced readouts, including high-content imaging, functional assays, and multi-omics analysis to provide a comprehensive understanding of your therapeutic's impact.

Our Workflow

Move Beyond Static Cultures. Embrace Dynamic, Human-Relevant Physiology.

Partner with Creative Biolabs to leverage the predictive power of Organ-on-a-Chip technology. Contact our specialists today to design a study that will deliver clear, actionable, and transformative insights for your therapeutic program.

Speak with an Organ-on-a-Chip Expert