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Paliperidone [Dopamine D2 Receptor; 5-HT2A Antagonist]

[CAT#: MOD2005ZP229]

5-HT2A and D2 antagonist. Antipsychotic.

Target:
DRD2

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Description
5-HT2A and D2 antagonists (h5-HT2A receptor Ki = 0.4 nM). Risperidone metabolite. Atypical antipsychotics.
Synonyms
9-Hydroxyrisperidone; 9-OH-risperidone
Chemical Name
3-[2-[4-(6-Fluoro-1,2-benzisoxazol- 3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hy droxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Modulator Type
Antagonist
Relevant Disease
Neurological Disorders
Molecular Weight
426.48
Chemical Formula
C23H27FN4O3
SMILES
FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(C(O)CCC5)N5C4=O)CC3)=NO2)C=C1
Solubility
Soluble in DMSO (10mM)
CAS NO.
144598-75-4
PubChem Substance ID
115237
Purity
>98%
Storage
+4°C
Shipping
Room Temperature
Research Use Only
For research use only
Target
DRD2
Official Name
DRD2
Alternative Names
The dopamine receptor D2, also known as D2R, is a protein encoded by the DRD2 gene in humans. The dopamine D2 receptor is the main receptor for most antipsychotic drugs. The structure of DRD2 combined with the atypical antipsychotic drug risperidone has been determined.

This gene encodes the D2 subtype of the dopamine receptor, which is coupled to the Gi subtype of the G protein-coupled receptor. This G protein-coupled receptor can inhibit the activity of adenylate cyclase.

In mice, the modulation and exploration of D2R surface expression by neurocalcium sensor 1 (NCS-1) in the dentate gyrus is related to synaptic plasticity and memory formation. A recent study showed that D2R has a potential role in restoring forearm cortical fear memory.

In Drosophila, activation of D2 autoreceptors protects dopamine neurons from MPP+-induced cell death, a toxin that mimics the pathology of Parkinson's disease.
Modulators
Biomaterials
Neural Proteins & Peptides
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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