
Quetiapine hemifumarate [Dopamine D2 Receptor; 5-HT2 Antagonist]
[CAT#: MOD2005ZP232]
5-HT2 and D2 antagonist. Atypical antipsychotic.
- Target:
- DRD2
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This gene encodes the D2 subtype of the dopamine receptor, which is coupled to the Gi subtype of the G protein-coupled receptor. This G protein-coupled receptor can inhibit the activity of adenylate cyclase.
In mice, the modulation and exploration of D2R surface expression by neurocalcium sensor 1 (NCS-1) in the dentate gyrus is related to synaptic plasticity and memory formation. A recent study showed that D2R has a potential role in restoring forearm cortical fear memory.
In Drosophila, activation of D2 autoreceptors protects dopamine neurons from MPP+-induced cell death, a toxin that mimics the pathology of Parkinson's disease.