Rat Anti-Mouse RAC1 Monoclonal Antibody (CBP4250)

Product Overview

Description

Rac1, Rac2 and Rac3 are three isoforms of Rac protein that exist in mammals. Rac proteins belong to the Rho-GTPase family, which regulate many cellular processes. Rac1 has been reported to play important role in actin reorganization, microtubule stability, cell cycle, motility, epithelial differentiation, and glucose uptake. Rac1 has also been reported to activate several protein kinases such as PAK-1, PI(4)P5-K, and thus is involved in cellular signaling cascades. Mutations in Rac1 have been recently linked to several cancers including melanoma and non-small cell lung cancer, making this protein a potential therapeutic target.

Immunogen

Recombinant full-length Rac1 protein

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2b, κ

Clone Number

CBP4250

Applications

IHC-P

Application Notes

IHC-P (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

RAC1

Official Name

RAC1

Full Name

Ras-related C3 botulinum toxin substrate 1

Alternative Names

RAC1; MIG5; Rac-1; TC-25; p21-Rac1; ras-related C3 botulinum toxin substrate 1 (rho family; small GTP binding protein Rac1); Rac family small GTPase 1; MRD48

Gene ID

5879

Uniprot ID

P63000

References

1. Payapilly A, Malliri A. 2018. Curr. Opin. Cell. Biol. 2018.04.009.
2. Melzer C, et al. 2017. Cell. Commun. Signal. s12964-017-0175-0.
3. Zou T, et al. 2017. Clin. Genet. cge.12908.

Publications