Creative Biolabs

Recombinant BDNF Protein, Active

[CAT#: NPR2008PZ480]

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Description
aa 129 to 247 refers to the full length mature form.
This product does not contain signal peptide or propeptide.
Biological Activity
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.

The active form of BDNF is a 27.0 kDa, dimer formed by two identical 119 amino acid subunits that is held together by strong hydrophobic interactions.
Expression Host
Escherichia coli
Length
Full length protein
Nature
Recombinant
Amino Acids
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Accession Number
P23560
Molecule Mass
27 kDa
Applications
SDS-PAGE; WB
Research Areas
Neurodegeneration
Pathways
Huntington's Disease Signaling
Form
Lyophilized
Purity
>= 95% SDS-PAGE. Purity by HPLC>=95%.
Shipping
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
n/a
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Storage
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.

For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Handling Advice
Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
This solution can then be diluted into other aqueous buffers and stored at 4C for 1 week or -20C for future use.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
BDNF
Official Name
BDNF
Full Name
Brain Derived Neurotrophic Factor
Alternative Names
Brain Derived Neurotrophic Factor; Neurotrophin; Abrineurin; Brain-Derived Neurotrophic Factor; ANON2; BULN2;
Gene ID
627 (Human); 12064 (Mouse); 24225 (Rat)
Uniprot ID
P23560 (Human); P21237 (Mouse); P23363 (Rat)
Neural Proteins & Peptides
Kits
Neural Antibodies
Biomaterials
For Research Use Only. Not For Clinical Use.
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