Creative Biolabs

Recombinant Human Acetylcholinesterase Protien

[CAT#: NPP2007FY113]

Species:
Human
Sequence:
AA 32-614

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Description
Acetylcholinesterase (AChE) is the main enzyme that hydrolyzes acetylcholine (a key neurotransmitter used in synaptic transmission) into acetate and choline in the central nervous system and peripheral nervous system. The mild inhibition of AChE has been shown to have therapeutic significance with Alzheimer's disease (AD), myasthenia gravis and glaucoma. On the contrary, strong inhibition of AChE can lead to cholinergic poisoning. Irregular expression of AChE has also been found in different types of tumors, indicating that AChE is involved in the regulation of tumor development. Therefore, AChE inhibitors may be used in cancer treatment in the future.
Species
Human
Expression Host
HEK 293 cells
Sequence
AA 32-614
Accession Number
P22303
Molecule Mass
~70 kDa (C terminal 6×His tag)
Relevant Diseases
Alzheimer's Disease
Form
Lyophilized powder
Formulation
0.22 μm filtered PBS, pH 7.4 with 50% glycerol
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Carrier Protein
BSA free
Purity
>95%
Shipping
Gel Pack
Storage
-20°C
Handling Advice
Centrifuge the vial prior to opening.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Acetylcholinesterase
Official Name
ACHE
Full Name
Acetylcholinesterase
Alternative Names
ACHE; AChE; acetylhydrolase; acetylcholinesterase (Yt blood group); ACEE; ARN-YT; acetylcholinesterase (Cartwright blood group); true cholinesterase (dated synonym)
Gene ID
43 (Human); 11423 (Mouse); 83817 (Rat)
Uniprot ID
P22303 (Human); P37136 (Mouse)
Figure 1 2 µg of the recombinant AChE is loaded under reducing and non-reducing conditions and stained with Coomassie Blue. Lane M: MW Marker, Lane 1: reducing (monomer), Lane 2: non-reducing conditions (monomer and dimer form) AChE.


Figure 2 Acetylcholinesterase Enzyme activity: The specific activity of AChE is> 500 U/mg assayed with Acetylcholinesterase Inhibitor Screening Kit (K197).
For Research Use Only. Not For Clinical Use.
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