Creative Biolabs

Recombinant Human Apo E Protien

[CAT#: NPP2007FY214]

Apolipoprotein E acts as a ligand for low-density receptors.

Species:
Human

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Description
Apolipoprotein E acts as a ligand for low-density receptors and participates in the transport and redistribution of cholesterol and other lipids. Other functions include immune regulation and cell growth regulation and differentiation. It is believed that Apo E is involved in tissue repair because of the increased protein content found in the areas of peripheral nerve injury and regeneration. The mutant form is associated with familial type III hyperlipoproteinemia. The concentration of Apo E in normal plasma is 5 mg per 100 ml. In addition to promoting lipid solubilization, these proteins also help maintain the structural integrity of lipoproteins, act as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Large amounts of ApoE are produced in the liver and brain and in almost every organ. ApoE is an important component of all plasma lipoproteins. It interacts with specific ApoE receptors, allowing liver cells to take up chylomicron residues, which is an essential step in the process of normal lipid metabolism. It also binds to the LDL receptor (Apo B/E). The deficiency of ApoE is the cause of type III hyperlipoproteinemia. There are three main isoforms of ApoE. E2, E3 and E4, the difference between them is only one amino acid substitution.
Species
Human
Expression Host
Human plasma. Prepared from plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Accession Number
P02649
Molecule Mass
34 kDa
Form
Frozen
Formulation
Frozen in 50 mM NH4HCO3, pH 8.0
Carrier Protein
BSA free
Purity
≥95%
Shipping
Dry Ice
Storage
-80°C
Handling Advice
Centrifuge the vial prior to opening.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Apo E
Official Name
ApoE
Full Name
Apolipoprotein E
Alternative Names
APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4
Gene ID
348 (Human); 11816 (Mouse)
Uniprot ID
P02649 (Human); P08226 (Mouse)
Figure 1 Apolipoprotein E, Human Plasma.
Neural Cell Lines
Kits
Neural Genes
Neural Proteins & Peptides
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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