Creative Biolabs

Recombinant Human BDNF Protein, Animal Component-Free

[CAT#: NGF2005ZP104]

Brain-derived neurotrophic factor, animal component-free

Species:
Human

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Description
Brain-derived neurotrophic factor (BDNF), such as nerve growth factor (NGF), neurotrophin-3 (NT-3) and Neurotrophin-4 (NT-4), are members of the NGF family of neurotrophins and are neurotrophic factors Required. Differentiation and survival of specific neuronal subpopulations in the central nervous system and peripheral nervous system. BDNF binds to the TRKB kinase receptor with high affinity and activates the AKT and ERK pathways. It is expressed in the hippocampus, cortex and synapse of the basal forebrain. BDNF regulates the synaptic transmission and plasticity of adult synapses in the central nervous system and contributes to adaptive neuronal responses, including long-term enhancement, long-term depression, certain forms of short-term synaptic plasticity, and steady-state regulation of neuronal excitability. It also plays a role in neurogenesis by promoting the survival and growth of dorsal root ganglion cells and hippocampal and cortical neurons. Together with glial cell line-derived neurotrophic factor (GDNF) and other supplements, BDNF is commonly used to differentiate neural progenitor cells derived from human pluripotent stem cells (hPSC) into neurons.
Species
Human
Nature
Recombinant
Molecule Mass
13.6 kDa monomer; 27.3 kDa dimer
Conjugation
Unconjugated
Relevant Diseases
Central Hypoventilation Syndrome; Congenital; Wilms Tumor; Aniridia; Genitourinary Anomalies; Mental Retardation Syndrome
Applications
FuncS; WB
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
W: Reduce sample handling and use SDS-Page. The band size is approximately 253 kDa.
FS: Complement activation after incubation with CVF is tested by lysis of sheep red blood cells.
Form
Liquid or Lyophilized
Concentration
Batch Dependent
Carrier Protein
Animal Free
Purification
The protein was resolved by SDS-PAGE and the gel was stained with Comassie blue.
Purity
≥ 95%
Shipping
The product is shipped at 4℃. Upon receipt, store it immediately at the temperature recommended below.
Storage
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -129 °C under sterile conditions after reconstitution.
Notes: avoid repeated freeze-thaw cycles.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
BDNF
Official Name
BDNF
Full Name
Brain Derived Neurotrophic Factor
Alternative Names
Brain Derived Neurotrophic Factor; Neurotrophin; Abrineurin; Brain-Derived Neurotrophic Factor; ANON2; BULN2;
Gene ID
627 (Human); 12064 (Mouse); 24225 (Rat)
Uniprot ID
P23560 (Human); P21237 (Mouse); P23363 (Rat)
Neural Proteins & Peptides
Neural Antibodies
Kits
Biomaterials
For Research Use Only. Not For Clinical Use.
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