Creative Biolabs

Recombinant Human IL-13 (Gly21-Asn132) Protein, Carrier Free

[CAT#: NPP201042LS]

Human IL-13 Recombinant Protein Product

Species:
Human
Tag:
C-His

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Description
Human IL-13 was initially cloned from cDNA libraries of activated T cells. IL-13 is an immunoregulatory cytokine secreted predominantly by activated T(H)2 cells, and it is a key mediator in the pathogenesis of allergic inflammation. IL-13 shares many functional properties with IL-4, and they share a common receptor subunit, the alpha subunit of the IL-4 receptor (IL-4Ralpha). IL-13 mediates its effects by interacting with a complex receptor system comprised of IL-4Ralpha and two IL-13 binding proteins, IL-13Ralpha1 and IL-13Ralpha2. Ligation of the IL-13 receptor complex results in signaling via the insulin receptor substrate (IRS)-1 and 2 and STAT-6 pathways. IL-13, like IL-4, is a cytokine produced by T(H)2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). IL-13 has been implicated in airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.
Species
Human
Expression Host
E. coli
Nature
Recombinant
Construction
Gly21-Asn132
Accession Number
X69079
Molecule Mass
12.3 kD
N-terminal
Glycine
Tag
C-His
Conjugation
Unconjugated
Relevant Diseases
Neurological Disorders
Applications
ELISA
Application Notes
The optimal working dilutions shoµld be determined by the end user.
Research Areas
Neuroinflammation
Form
Liquid
Concentration
0.2 mg/ml
Formulation
0.22µm filtered protein solution is in 10mM NaH2PO4, 150mM NaCl, pH 7.2.
Carrier Protein
Carrier Free
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
Product is shipped at ambient temperature. Upon receipt, store lyophilized powder at ≤ -20°C. Reconstituted peptide should be aliquoted and stored at ≤ -20°C. Do not freeze/thaw.
Storage
Unopened vial can be stored at -20°C or -70°C for six months. Avoid repeated freeze/thaw cycles.
Handling Advice
Stock solutions can also be prepared at 50 - 100 µg/mL in appropriate sterile buffer, carrier protein such as 0.2 - 1% BSA or HSA can be added when preparing the stock solution.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
IL-1β
Official Name
IL-13
Full Name
Interleukin 13
Alternative Names
IL13; IL-13; P600; interleukin 13
Gene ID
3596 (Human); 16163 (Mouse)
Uniprot ID
P35225 (Human); P20109 (Mouse)
1. Stevenson FT, et al. J Cell Physiol 152:223-231 1992.
2. Shi J, et al. J. Immunol. 179:1245-1253 2007.
3. Dinarello CA Cancer Metastasis Rev 25:307-313 2006.
4. Boost KM, et al. BMC Cancer 8:265 2008.
Neural Antibodies
Neural Genes
Neural Proteins & Peptides
For Research Use Only. Not For Clinical Use.
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