Creative Biolabs

Recombinant Human/Murine/Rat BDNF Protein

[CAT#: NPP2101002CR]

Unconjugated recombinant protein for BDNF

Species:
Chicken; Frog; Guinea Porcine; Hamster; Human
Sequence:
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR

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Description
It is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.
Species
Chicken; Frog; Guinea Porcine; Hamster; Human
Biological Activity
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
Expression Host
E.coli
Length
120 AA
Sequence
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Amino Acids
MetHisSerAspProAlaArgArgGlyGluLeuSerValCysAspSerIleSerGluTrp ValThrAlaAlaAspLysLysThrAlaValAspMetSerGlyGlyThrValThrValLeu GluLysValProValSerLysGlyGlnLeuLysGlnTyrPheTyrGluThrLysCysAsn ProMetGlyTyrThrLysGluGlyCysArgGlyIleAspLysArgHisTrpAsnSerGln CysArgThrThrGlnSerTyrValArgAlaLeuThrMetAspSerLysLysArgIleGly TrpArgPheIleArgIleAspThrSerCysValCysThrLeuThrIleLysArgGlyArg
Accession Number
P23560
Molecule Mass
27 kDa
Conjugation
Unconjugated
Relevant Diseases
Alzheimer's Disease; Huntington's Disease
Research Areas
Neuron; Neurotransmission
Form
Solid; white powder or thin/invisible film
Quality
The contents of this vial have been accurately determined.
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Shipping
The product is shipped at 5°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Keep tightly closed. Store at -21oC until use.
Handling Advice
Avoid inhalation. Avoid contact with eyes, skin, and clothing.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
BDNF
Official Name
BDNF
Full Name
Brain-derived neurotrophic factor
Alternative Names
BDNF; brain-derived neurotrophic factor; ANON2; BULN2; Brain-derived neurotrophic factor; brain derived neurotrophic factor
Gene ID
627(Human); 12064(Mouse); 24225(Rat)
Uniprot ID
P23560(Human); P21237(Mouse); P23363(Rat)
1. Truvé, K., Parris, T. Z., Vizlin-Hodzic, D., Salmela, S., Berger, E., Ågren, H., & Funa, K. (2020). Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder. Translational psychiatry, 10(1), 1-12. 2. Ebert, L. M., Yu, W., Gargett, T., Toubia, J., Kollis, P. M., Tea, M. N., ... & Brown, M. P. (2020). Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy. Clinical & translational immunology, 9(10), e1191. 3. Chen, Y., Kunath, T., Simpson, J., Homer, N., & Sylantyev, S. (2020). Synaptic signalling in a network of dopamine neurons: what prevents proper inter cellular crosstalk?. FEBS letters.
Neural Antibodies
Neural Cell Lines
Neural Proteins & Peptides
Biomaterials
Kits
For Research Use Only. Not For Clinical Use.
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