Creative Biolabs

Recombinant Mouse IL-1 Beta Protien

[CAT#: NPP2007FY61]

Species:
Mouse

Datasheet MSDS Request COA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Bulk Quote
Description
Recombinant mouse interleukin-1 beta. Interleukin-1 beta (IL-1 beta) is a 17.5 kDa pro-inflammatory cell-related cytokine, produced by monocytes, tissue macrophages, keratinocytes and other epithelial cells. IL-1β promotes the proliferation of memory T cells and the production of cytokines. It weakens regulatory T cell functions and prevents CD4 + CD25- self-reactive effectors from being suppressed. IL-1β signals downstream of myc and is necessary for tumor cell angiogenesis and invasiveness. IL-1β directly participates in neuronal damage in neurodegenerative diseases, and stimulates mitotic FGF-like activity, bone resorption and promotes the release of collagenase and prostaglandins from synovial cells.
Species
Mouse
Biological Activity
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is <0.002ng/ml, corresponding to a specific activity of> 5x108 units/mg.
Expression Host
E. coli
Molecule Mass
17.5 kDa (153 amino acid residues)
Relevant Diseases
Amyotrophic Lateral Sclerosis; Frontotemporal Dementia
Applications
WB; FuncS; ELISA
Application Notes
WB: 0.2-0.4ng/well
ELISA: 1.5-3.0ng/lane
Form
Lyophilised
Concentration
0.1 mg/ml after reconstitution
Carrier Protein
BSA free
Purity
>98% by SDS PAGE and HPLC analysis
Endotoxin Level
< 0.1 ng/ug
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Handling Advice
Reconstitute with 0.1 ml distilled water.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Il-1β
Official Name
IL1B
Full Name
Interleukin 1 beta
Alternative Names
IL1B; IL-1; IL1-BETA; IL1F2; interleukin 1 beta; IL1beta
Gene ID
16176(Human)
Uniprot ID
P10749(Human)
1. Allan, S. et al. (2005) Interleukin-1 and neuronal injury.
Neural Vectors
Neural Proteins & Peptides
Neural Antibodies
For Research Use Only. Not For Clinical Use.
Send Inquiry Send Inquiry
Inquiry Basket
compare

Go to compare