SB 216763 [GSK-3 Inhibitor]
A highly potent, selective cell permeable GSK-3 inhibitor
It also widely used in stem cell research, for example:
When cultured with MEF, maintain mESC (mouse embryonic stem cells) in a pluripotent state without LIF
Restore INS-dependent differentiation of C2ind myoblasts
Promote the transformation of human umbilical cord mesenchymal stem cells into neural precursors
Enhance hWJ-MSC cartilage formation and differentiation
Neurogenesis that increases differentiation of human neural progenitor cells
Promote the neural differentiation of CD117 positive hAFS cells into neural progenitor cells
Promote the proliferation of retinal stem cells
. Wang M, et al. The first synthesis of [(11)C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3).Bioorg Med Chem Lett. 2011 Jan 1;21(1):245-9. Epub 2010 Nov 11.
. Coghlan MP, et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol. 2000 Oct;7(10):793-803.
. The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium channel opening.