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Creative Biolabs
Product

Soluble Epoxide Hydrolase Inhibitor Screening Kit (Fluorometric), Human

[CAT#: NK1120FY016]

Soluble Epoxide Hydrolase Inhibitor Screening Kit (Fluorometric)

Applications:
Screening/Studying/Characterizing Soluble Epoxide Hydrolase Inhibitors

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Product Overview

Description

Soluble epoxy hydrolase (EC 3.3.2.10) is the highest cytoplasmic enzyme expressed in the liver, but it is commonly found in many organs such as the kidney, pancreas, pituitary, lymphatic tissue, muscle and gastrointestinal tract. It catalyzes the hydrolysis of epoxyeicosatrienoic acid (EET), that is, the formation of vicinal diols from epoxides derived from cytochrome P-450-mediated arachidonic acid metabolism. EET causes vasodilation and has anti-inflammatory effects. Since EET is hydrolyzed to glycol by soluble epoxy hydrolase, inhibiting this enzyme may enhance the beneficial properties of EET. This makes soluble epoxide hydrolase a very useful target for cardiovascular and analgesics. Assay Genie's soluble cyclohydrolase inhibitor screening kit is a microplate-based fluorescent detection kit for screening sEH inhibitors. Its measurement principle is based on the hydrolysis of non-fluorescent substrates into fluorescent products by sEH. It uses the well-known sEH inhibitor N-cyclohexyl-dodecylurea (NCND) as a positive control. The kit provides a simple and rapid method to screen/identify potential sEH inhibitors.

Species Reactivity

Human

Applications

Screening/Studying/Characterizing Soluble Epoxide Hydrolase Inhibitors

Relevant Diseases

Alzheimer's Disease

Research Areas

Neurodegeneration
Properites

Detection Method

Fluorescence (Ex/Em: 362/460 nm)

Components

sEH Assay Buffer
sEH Substrate
NCND (5 mM)
Human sEH Enzyme
Preparation and Storage

Storage

-20°C

Research Use Only

For research use only
Target Details

Target

EPHX2

Official Name

EPHX2

Full Name

Epoxide Hydrolase 2

Alternative Names

Epoxide Hydrolase 2; Epoxide Hydrolase 2, Cytoplasmic; Bifunctional Epoxide Hydrolase 2; Epoxide Hydrolase 2, Cytosolic; Epoxide Hydrolase, Soluble; Epoxide Hydratase; CEH; SEH;

Gene ID

2053(Human); 13850(Mouse)

Uniprot ID

P34913(Human); P34914(Mouse)
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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