Spinal and Bulbar Muscular Atrophy (SBMA) Model-based In Vitro Assay I

Name: Spinal and Bulbar Muscular Atrophy (SBMA) Model-based In Vitro Assay I
SKU: NRZP-0922-ZP1387
Rating: 5 (1 reviews)

[CAT#: NRZP-0922-ZP1387]

Species:: Human

Cell Types:: Neural Stem Cell

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Assay Overview

Description

Creative Biolabs offers custom in vitro functional assays based on neurological disease models. We have a variety of ready-to-use cell models which are validated for disease modeling, drug screening and toxicology testing. We also offer these assays as "cell line models" in a cryopreserved vial. Please feel free to contact us for more details.

Relevant Diseases

Spinal and Bulbar Muscular Atrophy (SBMA)

Cell Models Information

Cell Models Used

iNeu™ Human Neural Stem Cells - Spinal and Bulbar Muscular Atrophy (SBMA) Patient, Donor 55, Cat.#NRZP-0622-ZP82

Cell Models Overview

Spinal and bulbar muscle atrophy is a debilitating neurodegenerative disease caused by motor neuron degeneration and muscle atrophy in the brainstem and spinal cord. This condition is associated with mutations in the androgen receptor (AR) gene. Creative Biolabs cell lines derived from patients with spinal cord and bulbar muscular atrophy are excellent models for studying this rare genetic disorder. Creative Biolabs now offers custom human iPSC-derived brain cells from patients with spinal cord and bulbar muscular atrophy.

Cell Models Control

iNeu™ Human Neural Stem Cells (Male), Source Fibroblasts (74 Yr Donor), Validated, Cat.#NCL-2101-ZP04
iNeu™ Human Neural Stem Cells (Female), Source Fibroblasts (64 Yr Donor), Cat.#NCL-2101-ZP05

Cell Types

Neural Stem Cell

Model Applications

• Studying pathogenesis at the cellular level
• Studying neural network formation and signal transmission in neural culture
• Neurotoxicity testing
• Preclinical drug efficacy testing
• Co-culture studies