Tau shRNA Plasmid Expression Vector Set

Name: Tau shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY331
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY331]

Target:: Tau

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Product Overview

Description

A comprehensive kit for the specific knockdown of the microtubule-associated protein Tau (MAPT) gene, whose protein product forms neurofibrillary tangles in Alzheimer's disease and other tauopathies. The set includes three validated shRNA plasmid vectors targeting different sequences of the Tau mRNA for robust suppression, along with a non-targeting scrambled shRNA plasmid as a negative control. This kit is essential for studying Tau toxicity and its role in neurodegeneration.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

Tau

Full Name

Microtubule-associated protein tau

Gene ID

4137

Uniprot ID

P10636

Target Overview

Microtubule-associated protein tau (Tau) is a protein primarily found in neurons that plays a crucial role in stabilizing microtubules within axons. These microtubules are essential components of the neuronal cytoskeleton, acting as tracks for intracellular transport. In a class of neurodegenerative disorders known as "tauopathies," which includes Alzheimer's disease, Tau protein undergoes abnormal hyperphosphorylation. This chemical change causes it to detach from microtubules and aggregate into insoluble, paired helical filaments. These filaments accumulate inside neurons to form neurofibrillary tangles (NFTs), which are a primary pathological hallmark of these diseases.

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