Product
Total Tau Cellular Kit
[CAT#: NRP-0322-P2174]
This kit can be combined with our phospho-Tau kits. The kit is able to detect phosphorylated and unphosphorylated Tau protein in the same way.
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
Tau contains approximately 85 potential phosphate sites that can be heavily phosphorylated by many kinases such as CDK5, MAP kinase, or GSK3β, which is the main kinase of Tau. Hyperphosphorylation of Tau causes microtubules to rupture and Tau aggregates into Pairs of helical filaments or neurofibrillary tangles become entangled, and the cell dies.
Tau hyperphosphorylation and aggregation are associated with a variety of neurodegenerative diseases, such as Tauopathy, Parkinson's disease, and Alzheimer's disease. These two phenomena associated with beta-amyloid aggregation are major hallmarks of Alzheimer's disease.
Tau hyperphosphorylation and aggregation are associated with a variety of neurodegenerative diseases, such as Tauopathy, Parkinson's disease, and Alzheimer's disease. These two phenomena associated with beta-amyloid aggregation are major hallmarks of Alzheimer's disease.
Species Reactivity
Human
Relevant Diseases
Alzheimer's disease
Target Details
Target
Tau
Alternative Names
MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40
Publications
Publications (0)
Neural Genes
Neural Antibodies
Kits
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
