Creative Biolabs

UNC 0646 [GLP / G9a HMTase Inhibitor]

[CAT#: MOD2005ZP617]

A highly potent, selective G9a / GLP HMTase inhibitor

Target:
G9a / GLP HMTases

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Description
An efficient and selective G9a and G9a-like protein (GLP) histone lysine methyltransferase (HMTase) inhibitor (IC50 values ​​of 6 and <15 nM, respectively). The selectivity for G9a and GLP is higher than other methyltransferases.
Synonyms
Compound 6
Chemical Name
N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6 -methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolin amine
Modulator Type
Inhibitor
Relevant Disease
Neurological Disorders
Molecular Weight
1002.42
Chemical Formula
C36H59N7O2
SMILES
CC(C)N(CC6)CCCN6C1=NC(NC3CCN(C5CCCCC5)CC3)=C2C(C=C(OCCCN4CCCCC4)C(OC)=C2)=N1
Solubility
Soluble in DMSO (100mM) or ethanol (100mM)
CAS NO.
1320288-17-2
PubChem Substance ID
53315882
Purity
>99%
Storage
+4°C
Shipping
Room Temperature
Research Use Only
For research use only
Target
G9a / GLP HMTases
Official Name
G9a / GLP HMTases
Alternative Names
G9a / GLP HMTases

For Research Use Only. Not For Clinical Use.
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