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Creative Biolabs
Product

NeuroMab™ Anti-Apolipoprotein A1 BBB Shuttle Antibody, Clone D11-10

[CAT#: NRZP-1022-ZP3633]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; IHC

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

D11-10

Applications

WB; IHC
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

Apolipoprotein A1

Official Name

APOA1

Full Name

Apolipoprotein A1

Alternative Names

APOA1; entrez:335; apo(a); apolipoprotein A1; Apolipoprotein A-I; HPALP2
Product Pictures
ELISA

Figure 1 shows the detection of binding ability of ApoA1 monoclonal antibody D11-10. Recombinant human ApoA1 protein was coated on the plate, ApoA1 monoclonal antibody D11-10 was serially diluted, and detected by direct ELISA, wherein the binding force between ApoA1 monoclonal antibody D11-10 and recombinant human ApoA1 protein was 1.73×10-10M.

ELISA

Figure 2 is the comparison results of clinical samples detected by ApoA1 monoclonal antibody D11-10 and polyclonal antibody.

A: ApoA1 monoclonal antibody D11-10 and ApoA1 immunoturbidimetric kit were used to determine the content of ApoA1 in the samples of the control group and CHD group; b: ApoA1 monoclonal antibody D11-10 and ApoA1 immunoturbidimetric kit were used to determine the content of ApoA1 The ApoA1 content in the HDL-C≥1mM samples of the control group and coronary heart disease group was 1.37g/L (the 90% confidence interval of the control group determined by the ApoA1 monoclonal antibody was used as the cut-off value); 1.00g/L (the ApoA1 detection method described in the clinical test protocol critical value).

ELISA

Figure 3 shows the comparison of ApoA1 monoclonal antibody D11-10 to the three epitopes of ApoA1 in the CHD group and the control group.

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