Multiple Sclerosis Related Research Tools

Multiple sclerosis (MS), characterized by a proinflammatory and neurodegenerative process, is an inflammatory demyelinating disease of the central nervous system (CNS) that results in neuroaxonal damage. There are several types of MS, including Benign MS, Relapsing-Remitting MS (RRMS), Secondary Progressive MS (SPMS), Primary-Progressive MS (PPMS), and Malignant MS. Clinical expressions of MS vary depending on the locations of affected nerve fibers, but the most common symptoms are sensory loss, motor spinal cord symptoms, autonomic spinal cord symptoms, cerebellar symptoms, optic neuritis, trigeminal neuralgia, etc. Epidemiological data indicate that both genetic and environmental factors are important for the etiology of MS. Experimental autoimmune encephalomyelitis (EAE) is one of the most widely used models of MS. Besides, Theiler's murine encephalitis virus-induced demyelinating disease (TMEV-IDD) has been intensively used as a model for human demyelinating diseases, including MS. Demyelination induced in mice with a copper chelator cuprizone is also an important tool for MS studies.

Fig.1 B-cell mediated inflammatory pathway in MS.

B cells are important in MS because of their efficient antigen-presenting abilities. They produce cytokines that can change the microenvironment and mediate the negative effects through astrocyte populations, and they produce antibodies with potential roles in targeting ectopic lymphoid follicle like aggregates that persist long term in the brains of MS patients. The understanding of the role of B cells in MS presents opportunities for developing effective therapies. Therapeutic monoclonal antibodies (mAbs) utilized in the treatment of MS and their molecular targets are shown in Fig.2.

Fig.2 Therapeutic mAbs utilized in the treatment of MS and their molecular targets. (Dubey, 2015)

At Creative Biolabs, we have worked with some of the world-leading researchers, linking their invaluable insights to our scientific expertise to produce high-quality content across MS disease area. Creative Biolabs offers comprehensive products as well as high-quality customized services for our clients. We fully believe we have identified some of the best products and packages to aid your research, whilst also highlighting some of the most relevant current and future topics.

Summary of Popular Targets in Multiple Sclerosis

CD20	CD6
CD52	Muscarinic type 3 receptor (M3R)
CD25	IL-6R
α4-integrin	C5 complement protein
VCAM1	VLA-2
TLR9	IL-17A
Leucine-rich repeat and immunoglobulin domain-containing neurite outgrowth inhibitor receptor-interacting protein-1 (LINGO-1)
Sphingosine-1-phosphate 1/5 receptors

Reference

Dubey, D.; et al. Clinical management of multiple sclerosis and neuromyelitis optica with therapeutic monoclonal antibodies: approved therapies and emerging candidates. Expert review of clinical immunology. 2015, 11(1): 93-108.

Multiple Sclerosis (MS) Assay Service

For Research Use Only. Not For Clinical Use.

Target

GlyT

PRNP

NPR2

GLP1

Nestin

C9orf72

Neuropilin

BIRC5

GAD1

MA2

PROX1

HES5

SHANK2

CD3

GEMIN4

68kDa Neurofilament/NF-L

FE65

CD29

Somatostatin Receptor 1

Survivin

APP

Dopamine Beta Hydroxylase

Apo E

MOG

Neurofilament L

NLK

PACSIN3

HOMER3

VANGL2

Cathepsin B

SST1

NME2

Premade Viruses

iNeuMab™ Rabbit Anti-Laminin 5 Monoclonal Antibody (CBP7289) [CAT#: NAB-0720-Z9941]

Laminin 5 Rabbit Monoclonal Antibody

Host Species:: Rabbit

Species Reactivity:: Human

Applications:: IHC-P

Conjugation:: Unconjugated

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