Tracer Products
To comprehend the intricate systems of the brain, it is necessary to understand how neurons are connected, to describe the fine structure of neural circuits, and to recognize their functions. Creative Biolabs is committed to the development of tracing tools that can specifically label cell types and visualize conduction directions with controllable directionality to enable precise understanding and research of neural circuit networks.
If you have any specific requests or questions, please contact us right away. Our team of experienced experts is eager to work with you to solve your problems.
Product Overview
Creative Biolabs offers a wide range of neural tracing tools for precisely labeling neural circuits. These tools include traditional tracers (nonviral tracers) and recombinant viral vectors (viral tracers).
- Nonviral tracers are commonly employed to determine neural connections between different brain areas in experimental animals. These substances, which are versatile, extremely sensitive, and capable of selective anterograde and retrograde labeling, have been used to research neural circuits, such as dyes, dextran, proteins, and probes.
- Recombinant viral vectors become an effective tool for tracing neural network connections, overcoming the shortcomings of traditional tracers. The most commonly used viral tracing tools for neural circuit mapping are neurotropic viruses, which can infect nerve cells and spread across synapses along neural circuits, making them ideal tools for mapping neural circuits. Herpes simplex virus (HSV), pseudorabies virus (PRV), rabies virus (RV), and vesicular stomatitis virus (VSV) are commonly used neurotropic virus tracing tools. Adeno-associated virus (AAV) is a type of single-stranded DNA replication-deficient virus with a simple structure that has been discovered so far. It has the characteristics of high safety, low immunogenicity, wide range of host cells, and long expression time in vivo. A growing number of studies on the neural circuit are using AAV as a tool to trace the neural circuit.
Advantages
- Fast and high efficiency.
- Strong background in neural tracing tool.
- Hepatotoxicity and strong signal.
- Most competitive price.
Tracer Types
We have been involved in neuroscience research for many years and have accumulated extensive experience in neural tracing. We are proud to offer a wide range of neural tracer types, including but not limited to:
Trending Products
Creative Biolabs provides professional and convenient virus vector and nonviral tools for neural cell manipulation to study neural activity and the treatment of various neurological disorders.
Viral tracers
Cat# | Product Name | Types |
---|---|---|
NTC2101070CR | AAV2 Full Capsids, Reference Standards | Reference Materials |
NRZP-0722-ZP719 | rAAV-CAG-DIO-G-Flamp1 | Fluorescent cAMP Indicators. |
NTA-2012AD-P508 | pAAV-hSyn-DIO-XCaMP-R-WPRE | Calcium Indicator |
NRZP-0622-ZP616 | AAV-EF1a-mCherry-flex-dtA | Cell Ablation |
NTA-2012-ZP303 | AAV2/2Retro-CAG-DIO-EGFP-2A-TetTox-pA | Retrograde Tracing |
NTA-2012-ZP268 | AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA | Tetanus toxin |
NTA-2012-ZP78 | AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA | Chemogenetic inhibition |
NRZP-0622-ZP721 | AAV2/9-mDLX-iCRE-tdTomato-WPRE-pA | Cre Recombinase |
NRZP-0722-ZP719 | rAAV-CAG-DIO-G-Flamp1 | Neurotransmitter Sensor |
NTA-2012-ZP149 | AAV2/9-hSyn-Flpo-EGFP-WPRE-pA | Neural Tracing |
NTA-2011-ZP20 | VSV-eGFP [Vesicular Stomatitis Virus (VSV)] | Neural Tracing |
Nonviral tracers
Cat# | Product Name | Types |
---|---|---|
NTA-2011-ZP118 | Dextran-CYanine5.5 | Antegrade/Retrograde Tracer |
NRZP-0722-ZP124 | Dextran, NHS Activated, 200 kDa | Neural Tracing |
NRZP-0722-ZP22 | Dextran, Cy5 Labeled, 2000 kDa | Neural Tracing |
- Tracer Type:
- Virus Vector
- Tracer Type:
- Neurotransmitter sensor
- Applications:
- cAMP Sensor
Low toxicity; Strong tissue penetration ability; Different molecular weights
- Tracer Type:
- Dextan Conjugate
- Applications:
- Neural Tracing
Strong tissue penetration ability, less affected by biological autofluorescence
- Tracer Type:
- Dextan Conjugate
- Applications:
- Neural Tracing
- Tracer Type:
- Recombinase
- Applications:
- Neural Tracing
- Tracer Type:
- Fluorescent labeling
- Applications:
- Neural Circuit Mapping
New
New Fast Genetically Encoded Calcium Indicators: jGCaMP8
- Tracer Type:
- Calcium Sensor
- Applications:
- Calcium Sensor
New
New Fast Genetically Encoded Calcium Indicators: jGCaMP8
- Tracer Type:
- Calcium Sensor
- Applications:
- Calcium Sensor
New
New Fast Genetically Encoded Calcium Indicators: jGCaMP8
- Tracer Type:
- Calcium Sensor
- Applications:
- Calcium Sensor
New
New Fast Genetically Encoded Calcium Indicators: jGCaMP8
- Tracer Type:
- Calcium Sensor
- Applications:
- Calcium Sensor
New
New Fast Genetically Encoded Calcium Indicators: jGCaMP8
- Tracer Type:
- Calcium Sensor
- Applications:
- Calcium Sensor
New
New Fast Genetically Encoded Calcium Indicators: jGCaMP8
- Tracer Type:
- Calcium Sensor
- Applications:
- Calcium Sensor
- Tracer Type:
- Calcium Sensor
- Applications:
- Calcium Sensor
- Tracer Type:
- Fluorescent labeling
- Applications:
- Control
AAV2 Full Capsids
- Tracer Type:
- AAV Capsid
- Applications:
- Control
- Tracer Type:
- Neuronal Synaptic Depression
- Applications:
- Neural Tracing
- Tracer Type:
- Recombinase
- Applications:
- Recombinase
- Tracer Type:
- Optogenetics
- Applications:
- Optogenetics
- Tracer Type:
- Recombinase
- Applications:
- Recombinase
- Tracer Type:
- Dextan Conjugate
- Applications:
- Neural Tracing
- Tracer Type:
- Dextan Conjugate
- Applications:
- Neural Tracing
Anterograde, multisynaptic
- Tracer Type:
- Anterograde tracing virus
- Applications:
- Neural Tracing
Retrograde, multisynaptic
- Tracer Type:
- Retrograde tracing virus
- Applications:
- Neural Tracing
Express FLPo recombinase under CAG promoter in a Cre-dependent manner.
- Tracer Type:
- Recombinase
Cre-dependent and express CaMPARI2 under mature neuron specific hSyn promoter.
- Tracer Type:
- Calcium Sensor
Express FLPo recombinase under CAG promoter
- Tracer Type:
- Recombinase
- Tracer Type:
- Apoptosis/Killing
- Tracer Type:
- Helper virus
This AAV expresses oG driven by CAG Promoter in a Cre-dependent manner.
oG (optimized glycoprotein) is a codon-optimized version of a chimeric glycoprotein consisting of the transmembrane/cytoplasmic domain of B19G and the extracellular domain of rabies Pasteur virus strain glycoprotein. It has been reported that oG increases the tracing efficiency for long-distance input neurons up to 20-fold compared to B19G.
- Tracer Type:
- Neuronal circuitry
- Tracer Type:
- Chemogenetics
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- AAV2/9-hSyn-Flpo-EGFP-WPRE-pA (Cat#: NTA-2012-ZP149)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
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