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Creative Biolabs

Tracer Products

To comprehend the intricate systems of the brain, it is necessary to understand how neurons are connected, to describe the fine structure of neural circuits, and to recognize their functions. Creative Biolabs is committed to the development of tracing tools that can specifically label cell types and visualize conduction directions with controllable directionality to enable precise understanding and research of neural circuit networks.

If you have any specific requests or questions, please contact us right away. Our team of experienced experts is eager to work with you to solve your problems.

Product Overview

Creative Biolabs offers a wide range of neural tracing tools for precisely labeling neural circuits. These tools include traditional tracers (nonviral tracers) and recombinant viral vectors (viral tracers).

  • Nonviral tracers are commonly employed to determine neural connections between different brain areas in experimental animals. These substances, which are versatile, extremely sensitive, and capable of selective anterograde and retrograde labeling, have been used to research neural circuits, such as dyes, dextran, proteins, and probes.
  • Recombinant viral vectors become an effective tool for tracing neural network connections, overcoming the shortcomings of traditional tracers. The most commonly used viral tracing tools for neural circuit mapping are neurotropic viruses, which can infect nerve cells and spread across synapses along neural circuits, making them ideal tools for mapping neural circuits. Herpes simplex virus (HSV), pseudorabies virus (PRV), rabies virus (RV), and vesicular stomatitis virus (VSV) are commonly used neurotropic virus tracing tools. Adeno-associated virus (AAV) is a type of single-stranded DNA replication-deficient virus with a simple structure that has been discovered so far. It has the characteristics of high safety, low immunogenicity, wide range of host cells, and long expression time in vivo. A growing number of studies on the neural circuit are using AAV as a tool to trace the neural circuit.

Advantages

  • Fast and high efficiency.
  • Strong background in neural tracing tool.
  • Hepatotoxicity and strong signal.
  • Most competitive price.

Tracer Types

We have been involved in neuroscience research for many years and have accumulated extensive experience in neural tracing. We are proud to offer a wide range of neural tracer types, including but not limited to:

Trending Products

Creative Biolabs provides professional and convenient virus vector and nonviral tools for neural cell manipulation to study neural activity and the treatment of various neurological disorders.

Viral tracers

Cat# Product Name Types
NTC2101070CR AAV2 Full Capsids, Reference Standards Reference Materials
NRZP-0722-ZP719 rAAV-CAG-DIO-G-Flamp1 Fluorescent cAMP Indicators.
NTA-2012AD-P508 pAAV-hSyn-DIO-XCaMP-R-WPRE Calcium Indicator
NRZP-0622-ZP616 AAV-EF1a-mCherry-flex-dtA Cell Ablation
NTA-2012-ZP303 AAV2/2Retro-CAG-DIO-EGFP-2A-TetTox-pA Retrograde Tracing
NTA-2012-ZP268 AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA Tetanus toxin
NTA-2012-ZP78 AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA Chemogenetic inhibition
NRZP-0622-ZP721 AAV2/9-mDLX-iCRE-tdTomato-WPRE-pA Cre Recombinase
NRZP-0722-ZP719 rAAV-CAG-DIO-G-Flamp1 Neurotransmitter Sensor
NTA-2012-ZP149 AAV2/9-hSyn-Flpo-EGFP-WPRE-pA Neural Tracing
NTA-2011-ZP20 VSV-eGFP [Vesicular Stomatitis Virus (VSV)] Neural Tracing

Nonviral tracers

Cat# Product Name Types
NTA-2011-ZP118 Dextran-CYanine5.5 Antegrade/Retrograde Tracer
NRZP-0722-ZP124 Dextran, NHS Activated, 200 kDa Neural Tracing
NRZP-0722-ZP22 Dextran, Cy5 Labeled, 2000 kDa Neural Tracing
For Research Use Only. Not For Clinical Use.

Related Products
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Tracer Type:
Virus Vector
HOT rAAV-CAG-DIO-G-Flamp1 [CAT#: NRZP-0722-ZP719]

Fluorescent probe

Ready-to-use AAV particles

Tracer Type:
Neurotransmitter sensor
Applications:
cAMP Sensor
HOT Dextran, NHS Activated, 40 kDa [CAT#: NRZP-0722-ZP124]

Low toxicity; Strong tissue penetration ability; Different molecular weights

Tracer Type:
Dextan Conjugate
Applications:
Neural Tracing
HOT Dextran, Cy5 Labeled, 2000 kDa [CAT#: NRZP-0722-ZP22]

Strong tissue penetration ability, less affected by biological autofluorescence

Tracer Type:
Dextan Conjugate
Applications:
Neural Tracing
HOT AAV-mDLX-CRE-tdTomato [CAT#: NRZP-0622-ZP721]

Tracer Type:
Recombinase
Applications:
Neural Tracing
HOT AAV-EF1a-mCherry-flex-dtA [CAT#: NRZP-0622-ZP616]

Tracer Type:
Fluorescent labeling
Applications:
Neural Circuit Mapping
HOT pAAV-syn-FLEX-jGCaMP8s-WPRE [CAT#: NTA-2106-P066]

New

New Fast Genetically Encoded Calcium Indicators: jGCaMP8

Tracer Type:
Calcium Sensor
Applications:
Calcium Sensor
HOT pAAV-syn-FLEX-jGCaMP8m-WPRE [CAT#: NTA-2106-P065]

New

New Fast Genetically Encoded Calcium Indicators: jGCaMP8

Tracer Type:
Calcium Sensor
Applications:
Calcium Sensor
HOT pAAV-syn-FLEX-jGCaMP8f-WPRE [CAT#: NTA-2106-P064]

New

New Fast Genetically Encoded Calcium Indicators: jGCaMP8

Tracer Type:
Calcium Sensor
Applications:
Calcium Sensor
HOT pAAV-syn-jGCaMP8s-WPRE [CAT#: NTA-2106-P063]

New

New Fast Genetically Encoded Calcium Indicators: jGCaMP8

Tracer Type:
Calcium Sensor
Applications:
Calcium Sensor
HOT pAAV-syn-jGCaMP8m-WPRE [CAT#: NTA-2106-P062]

New

New Fast Genetically Encoded Calcium Indicators: jGCaMP8

Tracer Type:
Calcium Sensor
Applications:
Calcium Sensor
HOT pAAV-syn-jGCaMP8f-WPRE [CAT#: NTA-2106-P061]

New

New Fast Genetically Encoded Calcium Indicators: jGCaMP8

Tracer Type:
Calcium Sensor
Applications:
Calcium Sensor
HOT pAAV-hSyn-DIO-XCaMP-R-WPRE [CAT#: NTA-2012AD-P508]

Tracer Type:
Calcium Sensor
Applications:
Calcium Sensor
HOT pAAV-EF1a-DIO-EGFP-WPRE [CAT#: NTA-2012AD-P285]

Tracer Type:
Fluorescent labeling
Applications:
Control

AAV2 Full Capsids

Tracer Type:
AAV Capsid
Applications:
Control
Tracer Type:
Neuronal Synaptic Depression
Applications:
Neural Tracing
HOT AAV2/9-hSyn-Flpo-EGFP-WPRE-pA [CAT#: NTA-2012-ZP149]

Tracer Type:
Recombinase
Applications:
Recombinase
Tracer Type:
Optogenetics
Applications:
Optogenetics
Tracer Type:
Recombinase
Applications:
Recombinase
HOT Dextran-CYanine5.5 [CAT#: NTA-2011-ZP118]

Tracer Type:
Dextan Conjugate
Applications:
Neural Tracing
HOT Dextran-FITC [CAT#: NTA-2011-ZP110]

Tracer Type:
Dextan Conjugate
Applications:
Neural Tracing
HOT VSV-eGFP [CAT#: NTA-2011-ZP20]

Anterograde, multisynaptic

Tracer Type:
Anterograde tracing virus
Applications:
Neural Tracing
HOT PRV-CAG-EGFP [CAT#: NTA-2011-ZP14]

Retrograde, multisynaptic

Tracer Type:
Retrograde tracing virus
Applications:
Neural Tracing
AAV-CAG-FLEX-Flpo-WPRE-pA [CAT#: NRYF-0624-HZ3]

Express FLPo recombinase under CAG promoter in a Cre-dependent manner.

Tracer Type:
Recombinase
AAV-hSyn-DIO-CaMPARI2-WPRE [CAT#: NRYF-0524-HZ6]

Cre-dependent and express CaMPARI2 under mature neuron specific hSyn promoter.

Tracer Type:
Calcium Sensor
AAV-CAG-Flpo-WPRE-pA [CAT#: NRYF-0524-HZ1]

Express FLPo recombinase under CAG promoter

Tracer Type:
Recombinase
AAV-CMV_bGI-DIO-TK-EGFP-WPRE-pA [CAT#: NRYF-0624-HZ9]

Tracer Type:
Apoptosis/Killing
AAV-CAG-DIO-TVA-mCherry-WPRE-pA [CAT#: NRYF-0624-HZ7]

Tracer Type:
Helper virus
AAV-CAG-FLEX-oG-WPRE-pA [CAT#: NRYF-0624-HZ6]

This AAV expresses oG driven by CAG Promoter in a Cre-dependent manner.
oG (optimized glycoprotein) is a codon-optimized version of a chimeric glycoprotein consisting of the transmembrane/cytoplasmic domain of B19G and the extracellular domain of rabies Pasteur virus strain glycoprotein. It has been reported that oG increases the tracing efficiency for long-distance input neurons up to 20-fold compared to B19G.

Tracer Type:
Neuronal circuitry
Tracer Type:
Chemogenetics
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