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Creative Biolabs

Tracer Products

To comprehend the intricate systems of the brain, it is necessary to understand how neurons are connected, to describe the fine structure of neural circuits, and to recognize their functions. Creative Biolabs is committed to the development of tracing tools that can specifically label cell types and visualize conduction directions with controllable directionality to enable precise understanding and research of neural circuit networks.

If you have any specific requests or questions, please contact us right away. Our team of experienced experts are eager to work with you to solve your problems.

Product Overview Advantages Tracer Type Premade Viruses

Product Overview

Creative Biolabs offers a wide range of neural tracing tools for precise labeling of neural circuits. These tools include traditional tracers (nonviral tracers) and recombinant viral vectors (viral tracers).

  • Nonviral tracers are commonly employed to determine neural connections between different brain areas in experimental animals. These substances, which are versatile, extremely sensitive, and capable of selective anterograde and retrograde labeling, have been used to research neural circuits, such as dyes, dextran, proteins, and probes.
  • Virus tracers become an effective tool for tracing neural network connections, overcoming the shortcomings of traditional tracers. The most commonly used viral tracing tools for neural circuit mapping are neurotropic viruses, which can infect nerve cells and spread across synapses along neural circuits, making them ideal tools for mapping neural circuits. Herpes simplex virus (HSV), pseudorabies virus (PRV), rabies virus (RV), and vesicular stomatitis virus (VSV) are commonly used neurotropic virus tracing tools. Adeno-associated virus (AAV) is a type of single-stranded DNA replication-deficient virus with a simple structure that has been discovered so far. It has the characteristics of high safety, low immunogenicity, wide range of host cells and long expression time in vivo. A growing number of studies on the neural circuit are using AAV as a tool to trace the neural circuit.

Advantages

  • Fast and high efficiency
  • Strong background in neural tracing tool
  • Hepatotoxicity and strong signal
  • Most competitive price

Tracer Type

We have been involved in neuroscience research for many years and have accumulated extensive experience in neural tracing. We are proud to offer a wide range of neural tracer types, including but not limited to:

Intellectual Property

Creative Biolabs is a contract manufacturer that produces tailored viruses and vectors according to client specifications. Importantly, this manufacturing service does not grant Creative Biolabs any intellectual property ownership; all designs and associated intellectual property rights remain exclusively with the customer.

Certain vector components may be subject to third-party intellectual property rights. Creative Biolabs offers publicly available sequence information for these components as a convenience for reference only. The customer assumes full responsibility and liability for the use of these components in their custom vectors. By purchasing vectors containing such components, the customer confirms they have secured all necessary intellectual property licenses, including the right to engage Creative Biolabs for manufacturing.

For Research Use Only. Not For Clinical Use.

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We offer a comprehensive suite of services encompassing vector design, virus packaging, and analysis and testing for adeno-associated virus (AAV) applications.

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AAV-PHP.S Packaging

We offer a comprehensive suite of services encompassing vector design, virus packaging, and analysis and testing for adeno-associated virus (AAV) applications.

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AAV9 Packaging

Detects the presence of Mycoplasma contamination, a common and problematic contaminant in cell cultures.

Applications:
Mycoplasma Test

Measures the level of endotoxins (lipopolysaccharides from bacterial cell walls), which can cause fever and other adverse reactions.

Applications:
Bacterial Endotoxin Test

Confirms the absence of viable microorganisms (bacteria, fungi) in the final AAV product.

Applications:
Sterility Test

Measures the size of AAV particles (Z-average diameter), their polydispersity index (PDI) which indicates the uniformity of particle size, and the presence of aggregates, all of which impact efficacy and safety.

Applications:
AAV Particle Size/PDI/Aggregation

Confirms the sequence integrity of the plasmid DNA used for AAV production.

Applications:
Plasmid Sequence Analysis (Third-Generation Sequencing)

Provides a comprehensive and high-resolution sequence of the AAV genome, confirming the correct gene insert and detecting any unintended mutations.

Applications:
AAV Genome Sequence Analysis (Third-Generation Sequencing)

Assesses the completeness and structural integrity of the AAV genome within the capsid. (Repeated three times, indicating its high importance.)

Applications:
AAV Genome Integrity

A crucial safety test to ensure the absence of replication-competent AAV, which could replicate in the patient and cause unwanted immune responses.

Applications:
Replication-Competent AAV (rcAAV) Testing

Measures the concentration of Poloxamer 188, a surfactant often used for AAV stability.

Applications:
Poloxamer 188 Content

Detects residual iodixanol, a common density gradient medium used in purification.

Applications:
Iodixanol Residue

Quantifies remaining Triton X-100, another common detergent.

Applications:
TritonX Residue

Quantifies remaining Tween20, a common detergent.

Applications:
Tween20 Residue

Detects residual amounts of transfection reagents (like PEI or pro/FECTO VIR) used to introduce DNA into cells during production.

Applications:
Transfection Reagent Residue (PEI pro/FECTO VIR)

Measures any trace amounts of ligands used in affinity chromatography purification steps.

Applications:
Affinity Ligand Residue

Checks for any remaining nucleases (enzymes that degrade nucleic acids), which could compromise gene therapy products.

Applications:
Nuclease Residue

Detects residual bovine serum albumin (BSA), often used in cell culture media.

Applications:
Bovine Serum Albumin Residue

Quantifies any remaining proteins from the producer cells.

Applications:
Host Cell Protein Residue

Detects residual E1A protein from the adenoviral helper plasmid, a common contaminant.

Applications:
Host Cell E1A Residue

Measures any residual plasmid DNA used during the AAV production process.

Applications:
Plasmid DNA Residue

Analyzes the size of remaining host cell DNA fragments, which is important for safety.

Applications:
293 Host Cell DNA Fragment Size Distribution

Quantifies any remaining DNA from the HEK293 producer cells.

Applications:
293 Host Cell DNA Residue

Determines the precise molecular weight of the intact capsid proteins and the stoichiometric ratio of VP1, VP2, and VP3, which is critical for proper capsid assembly and function.

Applications:
AAV Capsid Intact Molecular Weight & Protein Type Ratio Analysis

A detailed analysis that identifies and sequences peptides from the capsid proteins, confirming their identity, post-translational modifications, and structural integrity.

Applications:
AAV Capsid Peptide Mapping

Quantifies the purity level of the capsid proteins.

Applications:
Capsid Protein Purity

Identifies the specific viral capsid proteins (VP1, VP2, VP3) present and assesses their overall purity.

Applications:
Capsid Protein Identification & Purity
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