Neurological Disease-based Assay
Creative Biolabs presents an extensive selection of cutting-edge in vitro assay services focused on neurological diseases. These assays provide a profound understanding of disease mechanisms at the cellular level, aid in drug discovery, and pave the way for personalized therapeutic strategies.
Benefiting from a strong foundation of expertise, our proficient team customizes assays for a range of neurological disorders, including but not limited to:
- AD In Vitro Assay
- PD In Vitro Assay
- HD In Vitro Assay
- ALS In Vitro Assay
- MS In Vitro Assay
- SMA In Vitro Assay
- DMD In Vitro Assay
- Ischemic Stroke In Vitro Assay
- Epilepsy In Vitro Assay
- Fragile X Syndrome In Vitro Assay
Available Cell Models for Neurodegenerative Diseases
Cell models serve as invaluable tools for dissecting disease pathways, screening potential therapeutics, and ultimately advancing our knowledge of these devastating conditions. At Creative Biolabs, we also offer a comprehensive array of cell models tailored for studying neurodegenerative diseases, each contributing uniquely to unraveling the complexities of these disorders:
- AD In Vitro Models
- PD In Vitro Models
- ALS In Vitro Models
- HD In Vitro Models
- Epilepsy In Vitro Disease Models
- Fragile X Syndrome (FXS) In Vitro Disease Models
There are several cell types available for studying neurodegenerative diseases. Here are some commonly used cell models in our in vitro assay service:
Primary Neuronal Cultures
Primary neurons isolated from brain tissue provide a close representation of native neuronal physiology. These cultures allow researchers to study disease-related processes in a controlled environment.
Induced Pluripotent Stem Cell (iPSC)-Derived Neurons
iPSCs are reprogrammed from patient-specific cells (often skin cells) and can be differentiated into various cell types, including neurons. This allows researchers to study disease mechanisms using cells with the patient's genetic background.
Neuroblastoma Cell Lines
Cell lines derived from neuroblastomas, such as SH-SY5Y and SK-N-SH, are commonly used due to their ability to differentiate into neuron-like cells. They are easy to culture and can be manipulated genetically.
3D Brain Organoids
3D brain organoids are self-organizing structures derived from iPSCs that mimic the cellular organization and functionality of specific brain regions. They can recapitulate some disease features and allow for more complex studies.
Astrocyte and Microglia
Neurodegenerative diseases involve interactions between different cell types in the brain. Models focusing on astrocytes and microglia can help study their roles in disease progression and inflammation.
Animal-Derived Cell Cultures
Cell lines derived from transgenic animals expressing neurodegenerative diseases-associated genes can provide insight into specific disease mechanisms.
Gene-Edited Cell Models
Techniques like CRISPR/Cas9 can be used to introduce disease-associated mutations into cell lines, allowing researchers to investigate the impact of specific genetic alterations on cellular function.
High-Content Screening Systems
High-content screening platforms combine cell-based models with our automated imaging and analysis techniques to screen large libraries of compounds for potential therapeutic effects.
Designing Customized Assays
At Creative Biolabs, we understand that every neuroscience inquiry is unique. Our dedicated team collaborates closely with researchers to design customized neural cell assays tailored to their specific questions. This ensures that the assays precisely target the neural cell types and functional aspects of interest, maximizing the quality and relevance of the data obtained.
Please feel free to contact us and discover how we take your neuroscience research to new heights.