Neurological Disease-based Assay

Primary Neuronal Cultures

Primary neurons isolated from brain tissue provide a close representation of native neuronal physiology. These cultures allow researchers to study disease-related processes in a controlled environment.

Induced Pluripotent Stem Cell (iPSC)-Derived Neurons

iPSCs are reprogrammed from patient-specific cells (often skin cells) and can be differentiated into various cell types, including neurons. This allows researchers to study disease mechanisms using cells with the patient's genetic background.

Neuroblastoma Cell Lines

Cell lines derived from neuroblastomas, such as SH-SY5Y and SK-N-SH, are commonly used due to their ability to differentiate into neuron-like cells. They are easy to culture and can be manipulated genetically.

3D Brain Organoids

3D brain organoids are self-organizing structures derived from iPSCs that mimic the cellular organization and functionality of specific brain regions. They can recapitulate some disease features and allow for more complex studies.

Astrocyte and Microglia

Neurodegenerative diseases involve interactions between different cell types in the brain. Models focusing on astrocytes and microglia can help study their roles in disease progression and inflammation.

Animal-Derived Cell Cultures

Cell lines derived from transgenic animals expressing neurodegenerative diseases-associated genes can provide insight into specific disease mechanisms.

Gene-Edited Cell Models

Techniques like CRISPR/Cas9 can be used to introduce disease-associated mutations into cell lines, allowing researchers to investigate the impact of specific genetic alterations on cellular function.

High-Content Screening Systems

High-content screening platforms combine cell-based models with our automated imaging and analysis techniques to screen large libraries of compounds for potential therapeutic effects.