Neurological Imaging

Creative Biolabs is a full-service contract research laboratory specializing in the in vitro, in vivo, discovery and development services for neuroscience research. We have established a comprehensive laboratory platform, equipped with state-of-the-art analytical equipment and testing facilities.

Overview

Neuroimaging is now the predominant technique in behavioral and cognitive neuroscience. The development of neuroimaging techniques such as high-resolution magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), or single photon emission tomography (SPECT) has promoted the identification of structural and functional characteristics underlying mental disorders to a great extent.

Neuroimaging Methods

Two of the most commonly used functional neuroimaging techniques are PET and SPECT. Another method commonly used for the study of brain fMRI. Differently from PET and SPECT, fMRI does not require the use of radioactive tracers. Also using the principles of MRI, it is possible to study the neurochemistry of the brain in vivo through magnetic resonance spectroscopy (MRS).

• MEG

Magnetoencephalography is a technique that relies on the naturally occurring magnetic fields in living organisms. With MEG, it is believed that the detectable neuronal signals originate from dendritic activity in the pyramidal cells of the cerebral cortex.

• PET

Positron emission tomography is a technique in which a radioactively labeled molecule is used. Because a wide range of molecules can be used, PET can provide measurements of blood flow, blood volume, brain metabolism (especially glucose), and neuroreceptor or neurotransmitter chemistry.

• TMS

Transcranial magnetic stimulation is unique among the techniques used to investigate function in the human brain. The TMS technique uses a magnetic field to induce an electric current in underlying brain tissue, thereby stimulating the neurons.

• MRI

MRI uses strong magnetic fields to create images of biological tissues, taking advantage of properties that are intrinsic to tissues of the brain and, as such, does not expose the subject to radiation. Among the various neuroimaging methods available, magnetic resonance imaging (MRI) is one of the most frequently employed techniques, mainly because of its high image resolution and ability to distinguish between different brain tissues.

Fig.1 Citation rates for the different modalities of functional neuroimaging. (Friston, 2009)

The Biomarker Development for Mental Disorders

Neuroimaging plays a critical role in psychiatry as it can potentially be used to identify biomarkers of disease, prognosis, or treatment, elucidate biological pathways, and help redefine diagnostic boundaries and inform and monitor new therapies. The insight into the neural mechanisms of psychiatric symptoms achieved through neuroimaging has already informed new nonpharmacological interventions. Imaging biomarkers have been relatively successful in the field of neurodegenerative disorders. Imaging biomarkers have also been used for proof-of-concept in the evaluation of new interventions for dementia.

Creative Biolabs is a leading international biotechnology company, we believe in the transformative power of science and technology. We have expertise and capabilities in providing high-quality solutions for your neurological research. If you are interested in our neurological imaging technology services, please feel free to contact us for more.

Reference

1. Friston, K.J. Modalities, modes, and models in functional neuroimaging. Science. 2009, 326(5951): 399-403.