Cell-depends Neurological Disease Solutions

The pathogenesis of neurological diseases is often multifactorial and not fully understood, making it very challenging to develop therapies for such diseases. Cell therapy can provide protective and anti-inflammatory effects on neural tissue, as well as replace and repair damaged neurons and glial cells, thereby reducing inflammation, rebuilding functional circuits, and relieving symptoms. This makes cell therapy and regenerative medicine the most promising candidates for achieving therapeutic goals in neurological diseases.

Several years of experience have rewarded Creative Biolabs with knowledge and technologies that ensure us provide the most reliable and thorough one-stop solution for neurological diseases to our clients around the world.

Fig 1. Two major approaches for cell therapy, neural repair and environmental amelioration. (Yasuhara, 2017)

Multiple Sclerosis (MS)

Hematopoietic stem cell transplantation, which temporarily eradicates autoreactive immune cells and reactivates abnormal immunity to self-antigens, has long been suggested for the management of intractable MS cases. However, clinical HSTC transplantation for MS remains difficult to achieve due to specific differences in experimental design and implementation procedure.

Amyotrophic Lateral Sclerosis (ALS)

ALS results in damage to the motor cortex and muscle wasting, and its neuropathology is accompanied by neuroinflammation caused by the activation of microglia and macrophages. At present, it has been confirmed in animal models that transplantation of MSCs or other stem cells can significantly delay the disease process, showing promising therapeutic potential.

Fig 2. Pathological features of ALS. (Böttcher, 2015)

Alzheimer's Disease (AD)

Exogenous cell therapy for AD aims to repair degenerated neuronal networks and restore cognitive function by implanting stem cells. The commonly used cells in recent research are embryonic stem cells (ESC), mesenchymal stem cells (MSC), brain-derived neural stem cells and induced pluripotent stem cells (iPSC), which can induce or secrete neuroprotective growth factors through cell delivery systems, or directly participate in the regeneration of neuronal circuits.

Fig 3. Stem cell treatment in AD. (Vasic, 2019)

Parkinson's Disease (PD)

The PD study initially used dopamine-containing fetal rat neurons to improve motor abnormalities in a rat model. In recent years, the theoretical basis of fetal substantia nigra cells, autologous DA-secreting cells, MSCs, ESCs and other stem cells in PD treatment has been gradually developed and studied as potential therapeutic methods.

Other Diseases

In addition to some common and well-studied diseases, Creative Biolabs also provides one-stop modalities services for other types of neurological diseases, including,

• Neurodegenerative Disorders
• Neuromuscular Disorders
• Psychiatric Disorders
• Pain
• Rare Diseases
• Brain Tumors
• Ophthalmology

Through our advanced technology and cutting-edge knowledge, Creative Biolabs now provides one-stop cell therapy solution services. Many thanks to the efforts of our outstanding R&D team, we offer reliable and comprehensive services such as stem cell extraction and transplantation, cell viability detection, cell secretion measurement, and neurological function testing to help you develop stable and feasible cell therapy for neurological diseases.

References

1. Yasuhara, T.; et al. Cell therapy for Parkinson’s disease. Cell Transplantation. 2017, 26(9): 1551-1559.
2. Böttcher, C.; Priller, J. Myeloid cell-based therapies in neurological disorders: How far have we come? Biochimica et Biophysica Acta. 2016, 1862: 323-328.
3. Vasic, V.; et al. Neurodegeneration and neuro-regeneration— Alzheimer’s disease and stem cell therapy. International Journal of Molecular Sciences. 2019, 20: 4272.