Schwann Cell Products

Schwann cells represent a significant glial cell type within the peripheral nervous system (PNS). They are instrumental in the development, differentiation, myelination, nourishment, and regeneration of the nervous system. Schwann cells are primarily divided into two types: myelinated and unmyelinated. Myelinated Schwann cells form myelin sheaths around neuronal axons, while unmyelinated Schwann cells form Remak bundles around small axons 0.5-1.5 microns in diameter.

Schwann cells have multiple functions in the nervous system, including protection of nerve fibers, myelination, nourishment, and regeneration. Their role in nerve injury and repair is particularly important. Therefore, in-depth research into the function and regulatory mechanisms of Schwann cells is of great importance for the development of new neuroprotective and therapeutic strategies.

At Creative Biolabs, our Schwann cell products are highly regarded by customers worldwide, enabling them to make breakthroughs in neurobiology. We offer a comprehensive range of Schwann cell products, including primary Schwann cells (from rat and mouse), primary human Schwann cells, and human induced pluripotent stem cell (hiPSC)-derived Schwann cells. To learn more about our products or to submit a project inquiry, please contact us today.

Product Overview

	Primary Schwann Cells Human Schwann Cells Mouse Schwann Cells from C57BL/6 Mouse Schwann Cells from CD1 Rat Schwann Cells
	Human iPSC-derived Schwann Cells iNeuTM Human Schwann Cell
	Immortalized Schwann Cells Immortalized Mouse/Rat Schwann Cell Line Immortalized Human Schwann Cell Line Immortalized Schwann Cell Line with GFP

Features & Benefits

• Cell Characteristics: long, spindle-shaped cells, adherent growth, purity greater than 90%, no HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, or fungal contamination.
• Culture Conditions: 5% CO₂, 37°C, Creative Biolabs-dedicated media is recommended.
• Transportation and Storage: product transport method is selected based on weather and distance, including frozen cell suspension and T-25 culture bottle transport at room temperature. Storage conditions are liquid nitrogen or incubator.

Applications

• Nerve Regeneration: Schwann cells play a key role in the repair process after nerve injury and can promote regeneration and repair of nerve fibers by secreting a variety of growth and neurotrophic factors.
• Neuroprotection: Schwann cells can participate in neuroprotection through a variety of mechanisms, including secretion of neurotrophic factors and regulation of immune responses.
• Disease Models: Schwann cells have broad applications in a variety of neurodegenerative diseases and neuropathies, including diabetic peripheral neuropathy, neurofibromatosis, etc.

For further information or to place an order, please contact us. We provide comprehensive technical support and after-sales service to ensure that any problems encountered by customers during use can be solved in a timely manner.

References

1. Tan, Dandan, et al. "Inhibition of RhoA-subfamily GTPases suppresses Schwann cell proliferation through regulating AKT pathway rather than ROCK pathway." Frontiers in cellular neuroscience 12 (2018): 437.
2. Hörner, Sarah Janice, et al. "Development and in vitro differentiation of Schwann cells." Cells 11.23 (2022): 3753.
3. Saiki, Tomokazu, et al. "The effects of insulin on immortalized rat Schwann cells, IFRS1." International Journal of Molecular Sciences 22.11 (2021): 5505.
4. Distributed under Open Access license CC BY 4.0 without modification.