- NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody,Clone NR1707P (Cat#: NRZP-1022-ZP4050)
- NeuroMab™ Anti-CD32b Antibody, Clone NR130P (Cat#: NRP-0422-P1803)
- NeuroMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- NeuroMab™ Anti-TNFα BBB Shuttle Antibody,Clone NR3088P (Cat#: NRZP-1022-ZP4105)
- NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- NeuroMab™ Anti-TREM2 BBB Shuttle Antibody, Clone NR19 (Cat#: NRZP-1022-ZP4114)
- NeuroMab™ Anti-GARP Antibody,Clone NR3348P (Cat#: NRP-0422-P1639)
- NeuroMab™ Anti-TREM2 Antibody, Clone NR65P (Cat#: NRP-0422-P792)
- NeuroMab™ Anti-Tau Antibody,Clone NR2218P (Cat#: NRP-0422-P2275)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- iNeu™ Retinal Pigment Epithelial Cells (RPE) (Cat#: NRZP-0323-ZP92)
- Human CMEC/D3 Cell Line, Blood-Brain Barrier Model (Cat#: NCL-2108-P020)
- iNeu™ Human Astrocyte (Cat#: NCL-2101-ZP37)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Mouse Hippocampal Neuron Cell HT22 (Cat#: NCL2110P001)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Mouse Retinal Ganglion Cells (Cat#: NCL2110P145)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Dextran-CYanine5.5 (Cat#: NTA-2011-ZP118)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- AAV2/9-hSyn-Flpo-EGFP-WPRE-pA (Cat#: NTA-2012-ZP149)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- AAV2/2Retro-CAG-DIO-EGFP-2A-TetTox-pA [Neural Tracing] (Cat#: NTA-2012-ZP303)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- ABCA1 Antisense Oligonucleotide (AK311445) (Cat#: NV-2106-P27)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroPro™ Anti-EPO BBB Shuttle Protein, HIRMab-EPO (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein, HIRMab-SGSH (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, cTfRMAb-TNFR (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, HIRMab-TNFR (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-ASA BBB Shuttle Protein, HIRMab-ASA (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, HIRMab-IDUA (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein, 8D3-IL-1RA (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-IDS BBB Shuttle Protein, HIRMab-IDS (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein, HIRMab-PON1 (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein, HIRMab-GDNF (Cat#: NRZP-0423-ZP509)
Neuronal Plasticity Assay
The human brain is a vast network frame that contains approximately 90 billion specialized cells that control our behavior and activities in whole. One of the most important and fundamental features of the brain is its ability to adapt to changes, which is also known as "neuronal plasticity". The plasticity of the nervous system grants us the ability to learn and remember as intelligent beings. Creative Biolabs' goal is to engage with one or more corporate partners in the biopharmaceutical industry. We will not only provide comprehensive quality data but also timely and effective solutions to any challenges that you face in neuronal plasticity.
Introduction to Neuronal Plasticity
Neuronal plasticity has been discovered at multiple scales. The top level is the adaptive behavior of organisms, the ability to learn and remember. The deeper level is the transformation in the structure and function of neuronal networks. There are related theories that if some of the neurons are selectively strengthened and co-excited, then the vinculum between these co-active neurons can be sustained and, more importantly, reimplemented in the future. Changes in local circuits and representational maps are caused by physical changes in the electrical network of neurons at the cellular level. Upon stimulation, neuronal, synaptic, protein, or genome structure transforms, transitioning from structural to functional plasticity.
Fig 1. Schematic view and microscopic images of neurons and flow of information. (Power & Schlaggar, 2017)
As for the molecular mechanisms of neuronal plasticity, it is currently recognized that the changes in neuronal structure and the generation of plasticity are caused by the combination of external factors, such as environmental stimuli, and genetic and biochemical influences. Receptors and different proteins in the synaptic compartment can achieve effective plastic changes. And all the known molecular mechanisms of neural transmission signaling pathways directly or indirectly participate in the realization of plasticity.
Neuronal Plasticity Assay
Neuronal plasticity is defined as the ability of the nervous system to respond to and remember new experiences by altering molecular structure, function, and network framework, in order to adapt to certain changes affecting neurological conditions. In-depth research on neuronal plasticity contributes to our further understanding of the nature of learning and memory abilities, as well as brain injury recovery. Neurogenesis, synaptogenesis, and neurite outgrowth/degeneration are essential features in the study of brain function. Creative Biolabs provides a range of customized assays to evaluate the neuronal plasticity, which mainly include but are not limited to:
As the specific molecular mechanisms that generate neuroplasticity are still not fully understood, the determination of neuroplasticity is mostly performed in cellular and animal models. Fluorescence staining and neuronal imaging are the bases of neuronal plasticity research, by which neuronal cell morphology and structural changes can be directly visualized through imaging observation. In addition, many experimental theories based on animal models have been developed to observe how neuronal plasticity shapes biological learning, memory and conditioning through behavioral analysis.
Fig 2. Single-whisker experiments can measure neuronal plasticity from a behavioral analysis perspective. (Sims, et al., 2015)
Our Tailored Neuronal Plasticity Assay Services
Creative Biolabs provides professional neuronal plasticity assay services to enhance your interpretation of pivotal systems and events in neuronal plasticity, and help you characterize the signaling and metabolic processes underlying specific neuronal plasticity phenomena. In addition to neuronal histological analysis and imaging analysis, we also provide you with a range of cell lines and animal models that can be used to study neuronal plasticity.
Please contact us for further information if you have any demands.
References
- Power, J.D.; Schlaggar, B.L. Neural plasticity across the lifespan. Wiley Interdiscip Rev Dev Biol. 2017, 6(1): 216.
- Sims, R.E.; et al. Astrocyte and neuronal plasticity in the somatosensory system. Neural Plasticity. 2015, 10: 732014.