Tension Headache Related Research Tools

A tension headache (TH) is the most common type of headache. The symptoms of TH involve a mild to moderate intensity headache that affects both sides of the head and usually feels like pressure or tightness around the head. It is pain or discomfort in the head, scalp, or neck, and is often associated with muscle tightness in these areas. THs occur when neck and scalp muscles become tense or contract. The muscle contractions can be a response to stress, depression, head injury, or anxiety. Any activity that causes the head to be held in one position for a long time without moving can cause a headache.

Fig.1 Putative pathophysiological targets of preventive therapies for TH (A) and the model for chronic TH (B). (Fumal, 2008)

The pathologic basis of TH is most likely derived from a combination of personal factors, environmental factors, and alteration of both peripheral and central pain pathways. Peripheral pain pathways receive pain signals from pericranial myofascial tissue and alteration of this pathway likely underlies episodic tension-type headache (ETTH). Treatment for TH includes acute therapy for individual attacks and preventive treatment to minimize the number of attacks that occur. Acute and preventive treatment can be used together. The current pharmacotherapy is non-specific and includes simple analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) for the episodic form and the tricyclic antidepressant amitriptyline for the chronic form. The popular targets are summarized below.

Glyceryl trinitrate

CGRP

Substance P

β-endorphin

5-HT

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Creative Biolabs now provides a variety of antibodies/agonists/antagonists against various targets in TH pain pathway to meet our clients’ requirements. Please submit your specific products or services inquiry to us, and we will reply with details. For some targets, the ready-to-use catalog may be not available. Please reach out to us for customized products or services. We also provide a full line of the culture medium, cell lines, toxins, and animal models for our clients. Contact us for more information.

Reference

Fumal, A.; Schoenen, J. Tension-type headache: current research and clinical management. The Lancet Neurology. 2008, 7(1): 70-83.

For Research Use Only. Not For Clinical Use.

Target

PDZK

NALP

67LR

Clusterin

BMAL1

Galanin

GFAP

GABA Transporter 3

PAK3

PGP9.5

SHANK2

NTRK2

CD171

Cathepsin K

NeuroD2

DCDC2

MSR1

NSE

RUNX1

STAT3 Phospho (Ser727)

HYPE

TORC2

Laminin 5

Cathepsin L / V / K / H

TMEM106B

MAG

CD147

Gemin 3

Cathepsin D

Engrailed/Invected

CRMP1

PPIB

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