Neuron Markers
Neurons are specialized cells of the central nervous system and the basic signal components of the brain. Neuronal dysfunction is an important factor in many neurological diseases. Therefore, the ability to identify, characterize, and analyze these different cells and their functions is essential for neuroscience and neuropathology research. Different neurons have different functions, and can be divided into several categories according to the neurotransmitters they express, their polarity, morphology, anatomical location, and the direction in which they transmit information.
Neurons are usually divided into the body (cell body), axon, dendrite and synapse. These unique compartments can be distinguished from different cell types in the nervous system using specific markers.
According to the polar states and anatomical positions, neurons can be divided into:
- Immature neurons
- Mature neurons
- Glutamatergic neurons
- GABAergic neurons
- Dopaminergic neurons
- Serotonergic neurons
- Cholinergic neurons
Overview of General Neuron Markers
| Neuron Types | Markers |
| Immature neuron | Doublecortin, NeuroD1, beta III Tubulin, TBR1, stathmin 1 |
| Mature neuron | NeuN, MAP2, 160 kD Neurofilament Medium, Synaptophysin, PSD95, 200 kDa neurofilament protein |
| Glutamatergic neuron | VGLUT1, vGluT2, NMDAR1, NMDAR2B, Growth Associated Protein 43, NMDAR2B, Glutaminase, Glutamine Synthetase |
| GABAergic neuron | GAT1, GABA B Receptor 1, GABA B Receptor 2, GAD65, GAD67 |
| Dopaminergic neuron | Tyrosine Hydroxylase, Dopamine Transporter, FOXA2, GIRK2, Nurr1, LMX1B |
| Serotonergic neuron | TPH, Serotonin Transporter, Pet1 |
| Cholinergic neurons | Choline Acetyltransferase, Acetylcholinesterase, vesicular acetylcholine transporter |
A List of Neuron Markers Provided by Creative Biolabs
- Cholinergic Neuron Markers
- Dopaminergic Neuron Markers
- GABAergic Neuron Markers
- Glutamatergic Neuron Markers
- Glycinergic Neuron Markers
- Serotonergic Neuron Markers
| Subcellular Localization | Markers | |
| Cytoplasmic | Acetylcholinesterase/ACHE | Choline Acetyltransferase/ChAT |
| Cell Surface | VAChT/SLC18A3 | |
| Subcellular Localization | Markers | |
| Nuclear |
HNF-3b/FoxA2 LMX1b |
Nurr1/NGFI-Bb/NR4A2 |
| Cytoplasmic | Tyrosine Hydroxylase | Dopamine b-Hydroxylase |
| Cell Surface | FOLR1 | SLC6A3/DAT1 |
| Subcellular Localization | Markers | |
| Cytoplasmic | GAD1/GAD67 | GAD2/GAD65 |
| Cell Surface |
GABAB R1 GABAB R2 |
GAT-1/SLC6A1 VIAAT/SLC32A1/VGA |
| Subcellular Localization | Markers | |
| Cytoplasmic | Glutamine Synthetase | |
| Cell Surface |
GRIN1/NMDAR1 GRIN2B/NMDAR2B |
VGLUT1/SLC17A7 VGLUT2/SLC17A6 |
| Subcellular Localization | Markers | |
| Cell Surface | VIAAT/SLC32A1/VGAT | |
| Subcellular Localization | Markers | |
| Nuclear | Pet1 | |
| Cytoplasmic | Dopa Decarboxylase/DDC | Tryptophan Hydroxylase/TPH-1 |
| Cell Surface | SLC6A4/5-HTTLPR/Serotonin Transporter | VMAT2 |
With our easy-to-use guide, make sure you choose the best cell marker tools for your research needs.
