Diagnostic-depends Neurological Disease Solutions

Creative Biolabs is 100% dedicated to neuroscience research. We are flexible to meet the unique needs of client projects. With our neural expertise and experience, we can help you answer key questions in your project. We will work with you as part of your team, not only to provide you with comprehensive, high-quality data but also to provide timely and effective solutions to any challenges you face.

Overview

Early and accurate differential diagnostics of neurodegenerative diseases is critical for two reasons. First, it has been shown that early diagnosis combined with current treatments can delay hospitalization, and the importance of the early diagnosis will dramatically increase as soon as disease-modifying drugs become available. Second, developing new treatments requires early and accurate identification of the right target populations.

Biomarkers of Neurodegeneration for Diagnosis

Biomarkers for neurodegenerative diseases need to be used not only to improve clinical diagnosis but also to facilitate the development and monitoring of effective disease-modifying therapies. The source and type of biomarkers have continued to grow for central nervous system diseases, from biofluid-based biomarkers to nucleic acids, tissue, and imaging. The continuous development of imaging methods has made important contributions to target identification and early diagnosis of biomarkers. Ideal biomarkers need to be easily quantifiable and measurable, reproducible, not subject to wide variation in the general population, and not subject to comorbid factors.

Tools in Neurodegenerative Disease Diagnosis

• Raman Spectroscopy

Raman spectroscopy is a reagent- and tag-free technique that provides rapid chemical and structural information by detecting the scattered light of molecules. The growing number of biomedical applications has shown the potential of Raman spectroscopy for the detection of novel biomarkers that could enable the rapid and accurate screening of disease susceptibility and onset. With significant development the power and simplicity of this technique have the potential to revolutionize neurodegenerative disease screening and diagnosis in the future.

Fig.1 Principle of Raman spectroscopy. (Devitt, 2018)

• Nanotechnology

Nanoparticles are very small particles (1-1000 nanometers), and their application in the diagnosis and treatment of malignant tumors and neurodegenerative diseases has led to new therapeutic approaches. Researchers are studying and developing a new treatment approach that uses nanotechnology to diagnosis neurodegenerative diseases, and therapeutic nanoplatform for neurological disorders. This treatment strategy will be used for the degeneration of neurodegenerative diseases. Current treatment options for neurodegenerative diseases only help treat symptoms, whereas nanotechnology approaches can reduce nerve cell apoptosis, reduce inflammation, and improve drug delivery in the brain.

Fig.2 Possible modifications of nanoparticles for prevention and diagnostics of neurodegeneration. (Pichla, 2020)

• Fluorescent Probe

In recent years, fluorescence probe-mediated biomarker visualization technology has attracted more and more attention in the early diagnosis of neurodegenerative diseases. Fluorescence diagnosis technology has become an attractive and potential alternative to diagnose and probe the progression of neurodegenerative diseases, because of being rapid, noninvasive, sensitive, simple, real-time, low-cost, and high-resolution in nature.

As a leading international biotechnology company. Creative Biolabs has the expertise to optimize each stage to ensure you get your desired outcome, achieving the highest levels of efficiency throughout. If you are interested in our services for diagnostics research, please feel free to contact us for more information.

References

1. Devitt, G.; et al. Raman spectroscopy: an emerging tool in neurodegenerative disease research and diagnosis. ACS chemical neuroscience. 2018, 9(3): 404-420.
2. Pichla, M.; et al. The antiaggregative and antiamyloidogenic properties of nanoparticles: a promising tool for the treatment and diagnostics of neurodegenerative diseases. Oxidative Medicine and Cellular Longevity. 2020.