Animal models are a fundamental tool in the life sciences. Murine models have become a main part of research in many laboratories as they are the most accessible animal model. Creative Biolabs has 10+ years of experience providing CRO services with a skilled team of scientists who will work with you in animal models of disease.
The perfect animal model of a disease would be a scaled-down replica of the human disease, representing all important components from cause to structural damage to symptoms. It would be structurally and quantitatively identical to human. For this, both the animal model and the human disease need to be very well understood. Such a model would have face-, predictive- and construct validity.
Types of Animal Models Used in Therapeutic Assessment
- Xenograft Models
The xenograft animal models utilizing human cells or tissue fragments require the use of immunocompromised mice to enable engraftment. They serve as a useful approach to evaluating the direct effects of humanized monoclonal antibodies.
- Syngeneic Models
A syngeneic model, where murine cell lines are injected subcutaneously in immune-competent murine hosts, is a model that avoids the immune-deficiencies found in other xenograft models.
- Orthotopic Models
Orthotopic models are more technically challenging to generate, however, they offer the advantage of examining effects on the microenvironment and the effect on the metastatic spread.
- Tumor Graft Models
Multiple research groups have now begun to report their experience in transplanting patient-derived tumors into immunodeficient mice as a tool for late-stage preclinical drug development.
Animal Breeding and Aging
The main goal of animal breeding is to select individuals with high reproductive value as parents and produce the next generation as soon as possible. Mixed linear models are commonly used in animal breeding to predict or estimate individual breeding values. Breeding values are used to select animals for breeding. Model organisms continue to form the basis of aging research, as ethical issues, and various other limiting factors complicate the use of human subjects in aging research. The laboratory mouse and rat are common models for the study of aging and age-related diseases.
Animal Models of Neurological Diseases at Creative Biolabs
The development of an animal model of Alzheimer's disease (AD) that best approximates the human disease has been the goal of many researchers. The study of these animal models is of great significance for clarifying the characteristics and Spatio-temporal evolution of brain cell abnormalities in AD patients, describing the mechanisms leading to brain dysfunction, and identifying new therapeutic targets and approaches.
Animal models of Parkinson's disease (PD) have come in various forms over the decades. All of these experimental models continue to be categorized into two main flavors: toxic and genetic.
Huntington's disease (HD) mouse models have allowed mutant and wild-type Huntingtin (Htt) expression and gene manipulation, the CAG repeat length, the size of protein fragments inserted into the genome, and the effects of stable and induced expression.
Fig.1 Types of animal models of diseases. (Laaldin, 2020)
Selecting the most appropriate in vivo model is essential during the drug development process to enable accurate modeling of therapeutic efficacy. Creative Biolabs has been selected by our large pharmaceutical and biotechnology clients for our expertise in the area of neuroscience research. Our goal is to provide our customers with affordable animal models and related services with reliable results.
Please feel free to contact us for more about our animal models related services.
- Laaldin, N.; et al. Animal models: bridging cross-species variation through animal biotechnology. Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries. 2020: 183-207.