Neurodegenerative Disorders Drug Discovery Service

Creative Biolabs focuses on providing one-stop-shop solutions for preclinical research into central nervous system disorders, rare diseases, and mental disorders, including drug discovery and development services. We have established a comprehensive in vitro and in vivo analysis platform and have provided a rich range of services for a large number of biopharmaceutical companies.

Overview of Neurodegenerative Disorders (NDs)

NDs are a broad class of disorders characterized by the progressive loss of disease-specific neural population and they include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and spinal cord injury. NDs are often due to misfolding of physiological proteins in both neural and glial cells. Gradual dysfunction of synapses, neurons, and glial cells, dementia, cognitive decline, brain function variations, and movement disorders are the early indicators of NDs.

Target Selection for NDs

The growing number of identified targets enlarges the range of potential clinical applications. However, many therapeutic agents and their related targets offer nothing beyond symptomatic relief and do not address the underlying pathology. It is therefore urgently necessary to identify promising pathogenic targets for gene therapy of NDs. Creative Biolabs can provide a range of mechanism of action (MoA) studies to help screen potential therapeutic targets for NDs.

Fig.1 Different biological processes have been involved in the development and pathogenesis of NDs. (Rahman, et al., 2021)

Neurology-related Drug Development Services at Creative Biolabs

• In Vitro Services
• In Vivo Services
• Ex Vivo Services
• Discovery Services
• Development Services

Solutions for Different NDs Therapy at Creative Biolabs

A variety of chronic progressive central nervous system disorders triggered by deterioration and eventual loss of neurons are implicated in neurodegenerative diseases. Parkinson's disease, well-characterized by loss of dopaminergic nigrostriatal neurons; Huntington's disease, which causes loss of spiny, medium-sized striatal neurons; and Alzheimer's disease induced by diffuse brain atrophy, are all generally known as NDs.

• Alzheimer's Disease (AD)
• Parkinson's Disease (PD)
• Amyotrophic Lateral Sclerosis (ALS)
• Huntington's Disease (HD)
• Lewy Body Dementia (LBD)
• Frontotemporal Lobe Dementia
• Multiple Sclerosis (MS)
• Pick's Disease
• Primary Lateral Sclerosis (PLS)
• Prion Diseases
• Wallerian Degeneration

At Creative Biolabs, we have the expertise to optimize each stage to ensure you get your desired outcome, achieving the highest levels of efficiency throughout. Our experienced technologists utilize our comprehensive, advanced technology platform to develop methods and innovative in-house technologies for the pharmaceutical industry, greatly advancing your research projects in the field of neurology. Please feel free to contact us for solutions to your Neurodegenerative Disorders (NDs) research projects.

Reference

1. Rahman, M.H.; et al. Therapeutic potential of natural products in treating neurodegenerative disorders and their future prospects and challenges. Molecules. 2021, 26(17): 5327.