Current Therapeutic Targets for Alzheimer's Disease
Alzheimer's disease (AD) is one of the most common multifactorial diseases, including a series of abnormal cell/molecular processes that occur in different areas of the brain. The disease is considered to be the main cause of dementia in the elderly. Pathophysiology involves the accumulation of extracellular plaques containing beta amyloid, which is produced by the breakdown of beta amyloid precursor protein (APP) in the brain. Another mechanism involves the formation of intracellular neurofibrillary tangles with hyperphosphorylated tau protein. Certain proteins, such as APOE, APP, BACE (β-amyloid lyase), secretase, PS1/2 and tau protein have been reported in the AD brain and are associated with diseases.
Creative Biolabs provides a variety of antibodies related to the biochemical pathways of Alzheimer’s disease, including APP, Tau protein, β-amyloid, ubiquitin, β-secretase, γ- secretase, GSK3 and Many other popular targets.