A Comprehensive Guide to Neural Markers
We understand the critical role that neural markers play in neuroscience research, and offer a variety of related services, including:
| Our Services | Descriptions |
| Antibody Discovery Services | We develop a variety of monoclonal antibodies against neural markers. For example, we provide our global customers with antibodies against various cell types in the nervous system, such as neurons, astrocytes, oligodendrocytes and microglia. There are also recombinant antibodies in different sizes to meet the needs of different situations. |
| Cell-based Assay | We offer a cutting-edge suite of advanced cellular assays, including the use of assays based on various cellular markers to determine cell viability, neural differentiation, neuronal phenotyping, glial cell phenotyping, and more. |
| Neuronal Cells Directed Differentiation Technology | We can provide our clients with efficient technical services for the directed differentiation of SCs into neural cells, as determined by immunofluorescence staining to detect the expression of neural markers. We rely on our proven technology platform for SCs to conduct personalized targeted differentiation studies of neural cells for you. |
Types of Neural Markers
Neural markers, also known as biomarkers, are biological indicators detectable in the brain, neural tissues, bodily fluids, or behavior, reflecting normal neuronal functioning, neurological disease processes, or the response to therapeutic interventions. Widely used in neuroscience research, these markers aid in neural circuit mapping, visualizing specific populations of neurons, and monitoring the health of neurons.
Classically, neural markers are categorized into structural markers, neurotransmitter markers, and functional markers.
- Structural markers relate to the physical and architectural configuration of neural tissues.
- Neurotransmitter markers are associated with neurotransmitter systems, playing a significant role in evaluating corresponding neuronal functions. For example, dopamine receptors, which can indicate the involvement of certain neural pathways.
- Functional markers, on the other hand, are affiliated with neuronal functions and processes, such as protein pathways. Emergent technologies have introduced genetic markers: those connected with specific genes, mutations, or modifications. These are particularly useful for studying genetic diseases or conditions with a significant genetic component. For example, expression of the Foxp2 gene has been associated with language development, providing a genetic marker for the study of language-related neural processes.
Antibodies to neural markers for the study of Alzheimer's Disease
| Cat. No | Product Name | Clonality | Applications |
| NRP-0422-P2292 | NeuroMab™ Anti-Amyloid Beta 1-15 Antibody, Clone mAb158 | Monoclonal | Inhib; In Vitro; In Vivo |
| NRZP-1022-ZP2792 | NeuroMab™ Anti-Amyloid Beta BBB Shuttle Antibody, Clone mAb158 | Monoclonal | Inhib; In Vitro; In Vivo |
| NRP-0422-P867 | NeuroMab™ Anti-Amyloid Beta 1-15 Antibody, Clone Donanemab | Monoclonal | In Vivo |
| NRP-0422-P2275 | NeuroMab™ Anti-Tau Antibody, Clone Alz50 | Monoclonal | WB; ELISA; In Vitro; In Vivo |
| NK-2106-P008 | Tau Monoclonal Antibody (AT120, HT7 and BT2 clone) | Monoclonal | |
| NRP-0422-P1683 | NeuroMab™ Anti-Tau Antibody, Clone HJ9.3 | Monoclonal | FC; ELISA; Inhib; In Vitro; In Vivo |
| NRP-0422-P1684 | NeuroMab™ Anti-Tau Antibody, Clone HJ8.5 | Monoclonal | FC; ELISA; Inhib; In Vitro; In Vivo |
| NRP-0422-p1686 | NeuroMab™ Anti-Tau Antibody, Clone HJ8.7 | Monoclonal | FC; ELISA; Inhib; In Vitro; In Vivo |
| NRP-0422-P1719 | NeuroMab™ Anti-pTau Antibody, Clone PHF1 | Monoclonal | WB; IHC; ICC; In Vitro; In Vivo |
| NRP-0422-P2293 | NeuroMab™ Anti-Tau Antibody, Clone 6C5 | Monoclonal | Inhib; Block; In Vitro; In Vivo |
| NAB-0720-Z6479 | NeuroMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) | Monoclonal | IHC-Fr; IHC-P; WB; ICC; IF; FC; EMDB; |
| NRP-0422-P792 | NeuroMab™ Anti-TREM2 Antibody, Clone NR65P | Monoclonal | FC; ELISA; In Vitro; Agonist; In Vivo |
| NRP-0422-P1220 | NeuroMab™ Anti-EPHB2 Antibody, Clone 2H9 (CBP8595) | Monoclonal | Antagonist |
| NRZP-1022-ZP3505 | NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody, Clone 14C7 | Monoclonal | WB; ELISA; Inhib; In Vitro; In Vivo; Antagonist |
| NRZP-1022-ZP3503 | NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody, Clone 5E5 | Monoclonal | WB; ELISA; Inhib; In Vitro; In Vivo; Antagonist |
| NRZP-0822-ZP4740 | NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) | Monoclonal | ELISA |
Antibodies to neural markers for the study of Parkinson's Disease
| Cat. No | Product Name | Clonality | Applications |
| NAB201250LS | Mouse Anti-Human α-Synuclein Phospho (Tyr39) Monoclonal Antibody (CBP3706) | Monoclonal | IHC-P; ELISA |
| NAB-08-PZ079 | Rabbit Monoclonal Antibody to Alpha-synuclein (phospho S129) | Monoclonal | WB; DB; ELISA; IHC-P |
| NRP-0422-P614 | NeuroMab™ Anti-Alpha Synuclein Antibody, Clone Syn-O2 | Monoclonal | DB; ELISA; FC; IHC; In Vitro |
| NAB-08-PZ735 | NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) | Monoclonal | ICC; IF; IHC-P; WB |
Applications of Neural Markers
The versatility of neural markers extends across various domains of neuroscience, facilitating a broad spectrum of applications that range from basic research to clinical interventions.
-
Understanding Neural Development
Genetic markers are commonly used to understand neurodevelopmental processes. By tracking the expression of specific genes during embryonic and postnatal development, researchers can reveal the molecular events that shape neural circuits. -
Mapping Neural Circuits
Neurological electrophysiology markers contribute significantly to the mapping of neural circuits in the brain. These techniques allow researchers to visualize the connectivity between different brain regions and understand how information is processed and transmitted. -
Drug Discovery and Development
Protein and molecular markers play a crucial role in drug discovery and development for neurological disorders. Identifying specific proteins associated with disease pathology allows for the development of targeted therapeutics. Neural markers serve as valuable tools in preclinical studies.
Summary of Neural Markers
In the complex field of neural exploration, each cell type exhibits unique markers that elucidate its distinctive functions and characteristics. Below we summarize a comprehensive overview of neural markers associated with various cell types.
| Cell Types | Markers |
| Neurons | Neurofilament Light (NEFL), Microtubule-Associated Protein 2 (MAP2), NeuN, GABA receptors, Electrophysiological patterns, Tyrosine Hydroxylase (TH), Calcium/Calmodulin-dependent Protein Kinase II (CamKII), Synaptophysin (SYP) |
| Astrocytes | Glial Fibrillary Acidic Protein (GFAP), Calcium-Binding Protein (S100B), Glutamate Aspartate Transporter (GLAST), AQP4 (Aquaporin-4) |
| Oligodendrocytes | Oligodendrocyte Transcription Factor 2 (Olig2), Myelin Oligodendrocyte Glycoprotein (MOG), Myelin Basic Protein (MBP), 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) |
| Microglia | Cluster of Differentiation 11b (CD11b), Ionized Calcium-Binding Adapter Molecule 1 (Iba1), CD68, CD45, Purinergic Receptor P2Y12 (P2Y12), TMEM119 |
| Schwann Cells | S100B, Neural/Glial Antigen 2 (NG2), Platelet-Derived Growth Factor Receptor Beta (PDGFR-β), Myelin Protein Zero (P0) |
| Enteric Neurons | Neuronal Helix-Loop-Helix Protein HuC/D, Choline Acetyltransferase (ChAT), Calretinin, Vasoactive Intestinal Peptide (VIP) |
| Ependymal Cells | GFAP, CD133, Aquaporin-1 (AQP1), Forkhead Box J1 (FOXJ1) |
| Pericytes | NG2, PDGFR-β, Alpha-Smooth Muscle Actin (α-SMA) |
| Tanycytes | S100B, GFAP, SRY-Box Transcription Factor 2 (SOX2), Neuropeptide Y (NPY), Leptin Receptor (LEPR) |
| Ependymocytes | GFAP, CD133, FOXJ1, AQP1, Marker of Proliferation Ki-67 (KI67) |
| Neural Stem Cells | Nestin, SOX2, GFAP, CD133, Doublecortin (DCX), Stage-Specific Embryonic Antigen-1 (SSEA-1) |
The advent and continued evolution of neural markers illuminate novel depths of our understanding of the brain and nervous system. They are a diversified and potent tool that contributes to the knowledge landscape of neuroscience, from base-level neurobiology to advanced neurological therapeutics.
Through continued research and development, Creative Biolabs stands on the new frontiers in neuroscience, providing neural markers as fundamental tools for neuroscience research. To stay up-to-date with the latest products and research tools, you can feel free to contact us.
