Creative Biolabs

Cerebral Aneurysm

Cerebral Aneurysm

The cerebral aneurysm is an abnormal bulge or ballooning of an artery in the brain that can put pressure on the surrounding nerves and brain tissues. It is also known as an intracranial aneurysm or brain aneurysm. There are three types of cerebral aneurysms: saccular aneurysms, fusiform aneurysms and dissecting aneurysms. Saccular aneurysms are the most common type, accounting for 90% of cerebral aneurysm cases.

A cerebral aneurysm accompanies robust structural changes in the vascular wall. Hemodynamic stress, inflammatory responses, extracellular matrix defects and degeneration have been suggested as the key components leading to the structural fragility in the arterial wall. However, the exact pathogenesis of cerebral aneurysm formation, growth, and rupture remains to be discovered.

Structural alteration of a cerebral aneurysm. Fig.1 Structural alteration of a cerebral aneurysm.

Creative Biolabs provides cerebral aneurysms related reagents, such as recombinant proteins, antibodies, cell lines and analytical kits. These high-quality products can be used in genetic, imaging, and laboratory tests and help to study the natural course and pathophysiology of cerebral aneurysms.

We are here to offer an opportunity to better identify aneurysms that have a high risk of rupture.

Pathophysiological Factors Involved in Aneurysm Formation

Molecular and histological changes
Endothelial cell
  • Endothelial cell apoptosis
  • Pro-inflammatory endothelial cell
  • Breakdown of endothelial barrier
  • E-selectin, P-selectin, VCAM-1, ICAM-1
Smooth muscle cell
  • Phenotypic switching from contractile to inflammatory type
  • Pro-inflammatory vascular smooth muscle cell
  • Smooth muscle cell apoptosis and degeneration
Inflammation
  • Infiltration of macrophages, neutrophils, T cell and mast cell
  • NF-kB, TNFα, MCP-1, IL-1p, IL-8, IL-17
  • COX2, PGE2, angiotensin II, NO, TLR-4
  • MMP 1, 2, 9 and Cathepsins
  • IgM, IgG
  • Complement (C3a, C5a)
Extracellular matrix
  • Alteration of collagen to elastic ratio
  • Breakdown of collagen and elastin cross-link
  • Matrix degradation
Internal elastic lamina
  • Fragmentation, and wavy appearance
  • Break down and degradation

For Research Use Only. Not For Clinical Use.
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